dc.contributor.author | Papadopoulou, A | |
dc.contributor.author | Musa, H | |
dc.contributor.author | Sivaganesan, M | |
dc.contributor.author | McCoy, D | |
dc.contributor.author | Deloukas, P | |
dc.contributor.author | Marouli, E | |
dc.date.accessioned | 2021-10-01T14:50:06Z | |
dc.date.available | 2021-08-19 | |
dc.date.available | 2021-10-01T14:50:06Z | |
dc.date.issued | 2021-09-03 | |
dc.identifier.citation | Papadopoulou A, Musa H, Sivaganesan M, McCoy D, Deloukas P, Marouli E (2021) COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases. PLoS ONE 16(9): e0256988. https://doi.org/10.1371/journal.pone.0256988 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/74337 | |
dc.description.abstract | Epidemiological studies suggest that individuals with comorbid conditions including diabetes, chronic lung, inflammatory and vascular disease, are at higher risk of adverse COVID-19 outcomes. Genome-wide association studies have identified several loci associated with increased susceptibility and severity for COVID-19. However, it is not clear whether these associations are genetically determined or not. We used a Phenome-Wide Association (PheWAS) approach to investigate the role of genetically determined COVID-19 susceptibility on disease related outcomes. PheWAS analyses were performed in order to identify traits and diseases related to COVID-19 susceptibility and severity, evaluated through a predictive COVID-19 risk score. We utilised phenotypic data in up to 400,000 individuals from the UK Biobank, including Hospital Episode Statistics and General Practice data. We identified a spectrum of associations between both genetically determined COVID-19 susceptibility and severity with a number of traits. COVID-19 risk was associated with increased risk for phlebitis and thrombophlebitis (OR = 1.11, p = 5.36e-08). We also identified significant signals between COVID-19 susceptibility with blood clots in the leg (OR = 1.1, p = 1.66e-16) and with increased risk for blood clots in the lung (OR = 1.12, p = 1.45 e-10). Our study identifies significant association of genetically determined COVID-19 with increased blood clot events in leg and lungs. The reported associations between both COVID-19 susceptibility and severity and other diseases adds to the identification and stratification of individuals at increased risk, adverse outcomes and long-term effects. | en_US |
dc.format.extent | e0256988 - ? | |
dc.language | eng | |
dc.publisher | Public Library of Science | en_US |
dc.relation.ispartof | PLoS One | |
dc.rights | Creative Commons Attribution License | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | COVID-19 susceptibility variants associate with blood clots, thrombophlebitis and circulatory diseases. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2021 Papadopoulou et al. | |
dc.identifier.doi | 10.1371/journal.pone.0256988 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34478452 | en_US |
pubs.issue | 9 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 16 | en_US |
dcterms.dateAccepted | 2021-08-19 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |