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dc.contributor.authorWhitehouse, A
dc.contributor.authorMiyashita, L
dc.contributor.authorGrigg, J
dc.contributor.authorMudway, I
dc.contributor.authorBarratt, B
dc.contributor.authorDove, R
dc.date.accessioned2021-05-18T14:21:27Z
dc.date.available2021-05-18T14:21:27Z
dc.date.issued2017-12-06
dc.identifier.issn0903-1936
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/71903
dc.description.abstractBackground: Although the mechanism underlying air pollution exposure’s adverse effects on lung function is unclear, oxidative stress is implicated in a range of adverse health effects of air pollution. Urinary 8-Oxo-2'-deoxyguanosine (8-oxo-dG) is a marker of DNA oxidation and oxidative stress. We sought to assess associations’ between oxidative stress and exposure to fossil fuel derived air pollution in children living in London (UK). Methods: After informed parental consent, healthy children aged 8-14 were recruited from schools in Greater London. Spot urine samples were analysed for 8-oxo-dG using a commercially available ELISA (Trevigen) and normalised against creatinine concentrations. Lung function (FEV1, FVC) was performed on the same day. Children’s short to long term exposure to particulate matter <10 microns (PM10), PM2.5, nitrogen dioxide (NO2), and nitrogen oxides (NOx) was using the London Air Quality Toolkit (LAQT) expressed as mean concentration over the previous 48h, 3mo and 12mo, based on home address. Preliminary statistical analysis was done by Spearman’s rank correlation. Results: 398 children were recruited. 8-oxo-dG was negatively correlated with both FEV1 (-0.166, p=0.002) and FVC (-0.119, p=0.024). 8-oxo-dG positively correlated with modelled exposure at the participants’ home address for the previous 48 h for; NO2 (0.172, p=0.003), NOX (0.161, p=0.005), PM10 (0.163, p=0.005), and PM2.5 (0.117, p=0.04). Discussion These results suggest that oxidative stress is one mechanism underlying the short-term effects of pollutant exposure on lung function in healthy children. We speculate that 8-oxo-dg is a putative biomarker for assessing exposure reduction interventions in this age group.en_US
dc.publisherEuropean Respiratory Societyen_US
dc.titleOxidative stress, short-term exposure to air pollution, and lung function in childrenen_US
dc.typeConference Proceedingen_US
dc.rights.holderCopyright ©the authors 2017
dc.identifier.doi10.1183/1393003.congress-2017.PA2645
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000431748902188&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.publisher-urlhttps://doi.org/10.1183/1393003.congress-2017.PA2645
pubs.volume50en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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