dc.contributor.author | Traylor, M | en_US |
dc.date.accessioned | 2021-03-24T15:34:21Z | |
dc.date.available | 2021-01-15 | en_US |
dc.identifier.issn | 1474-4422 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/70849 | |
dc.description.abstract | We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar
stroke and existing genome-wide association studies (GWAS). Patients were recruited from hospitals in the UK as part of
the UK DNA Lacunar Stroke studies 1 and 2 and from collaborators within the International Stroke Genetics Consortium.
Cases and controls were stratified by ancestry and two meta-analyses were done: a European ancestry analysis, and a
transethnic analysis that included all ancestry groups. We also did a multi-trait analysis of GWAS, in a joint analysis with
a study of cerebral white matter hyperintensities (an aetiologically related radiological trait), to find additional genetic
associations. We did a transcriptome-wide association study (TWAS) to detect genes for which expression is associated
with lacunar stroke; identified significantly enriched pathways using multi-marker analysis of genomic annotation; and
evaluated cardiovascular risk factors causally associated with the disease using mendelian randomisation. | |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Lancet Neurology | en_US |
dc.rights | This item is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.title | Twelve loci provide insights into the genetic basis of lacunar stroke and small vessel disease: a meta-analysis of genome-wide association studies | en_US |
dc.type | Article | |
dc.rights.holder | © 2021 The Author(s). Published by Elsevier Ltd. | |
pubs.notes | Not known | en_US |
pubs.publication-status | Accepted | en_US |
dcterms.dateAccepted | 2021-01-15 | en_US |