dc.contributor.author | Roller, M | |
dc.contributor.author | Stamper, E | |
dc.contributor.author | Villar, D | |
dc.contributor.author | Izuogu, O | |
dc.contributor.author | Martin, F | |
dc.contributor.author | Redmond, AM | |
dc.contributor.author | Ramachanderan, R | |
dc.contributor.author | Harewood, L | |
dc.contributor.author | Odom, DT | |
dc.contributor.author | Flicek, P | |
dc.date.accessioned | 2021-03-09T17:00:59Z | |
dc.date.available | 2021-01-04 | |
dc.date.available | 2021-03-09T17:00:59Z | |
dc.date.issued | 2021-02-18 | |
dc.identifier.citation | Roller, M., Stamper, E., Villar, D. et al. LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions. Genome Biol 22, 62 (2021). https://doi.org/10.1186/s13059-021-02260-y | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/70671 | |
dc.description.abstract | BACKGROUND: To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. RESULTS: The regulatory landscape around genes included both tissue-shared and tissue-specific regulatory regions, where tissue-specific promoters and enhancers evolved most rapidly. Genomic regions switching between promoters and enhancers were more common across species, and less common across tissues within a single species. Long Interspersed Nuclear Elements (LINEs) played recurrent evolutionary roles: LINE L1s were associated with tissue-specific regulatory regions, whereas more ancient LINE L2s were associated with tissue-shared regulatory regions and with those switching between promoter and enhancer signatures across species. CONCLUSIONS: Our analyses of the tissue-specificity and evolutionary stability among promoters and enhancers reveal how specific LINE families have helped shape the dynamic mammalian regulome. | en_US |
dc.format.extent | 62 - ? | |
dc.language | eng | |
dc.publisher | BioMed Central | en_US |
dc.relation.ispartof | Genome Biol | |
dc.rights | Creative Commons Attribution 4.0 International License | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Enhancers | en_US |
dc.subject | Gene regulation | en_US |
dc.subject | LINE L1 | en_US |
dc.subject | LINE L2 | en_US |
dc.subject | Long Interspersed Nuclear Elements (LINEs) | en_US |
dc.subject | Mammals | en_US |
dc.subject | Promoters | en_US |
dc.subject | Regulatory evolution | en_US |
dc.subject | Transposable elements | en_US |
dc.title | LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions. | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s). 2021 | |
dc.identifier.doi | 10.1186/s13059-021-02260-y | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/33602314 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.publisher-url | https://doi.org/10.1186/s13059-021-02260-y | |
pubs.volume | 22 | en_US |
dcterms.dateAccepted | 2021-01-04 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |