ESE audit on management of adult growth hormone deficiency in clinical practice
dc.contributor.author | Martel-Duguech, LM | |
dc.contributor.author | Jorgensen, JOL | |
dc.contributor.author | Korbonits, M | |
dc.contributor.author | Johannsson, G | |
dc.contributor.author | Webb, SM | |
dc.contributor.author | Amadidou, F | |
dc.contributor.author | Mintziori, G | |
dc.contributor.author | Arosio, M | |
dc.contributor.author | Giavoli, C | |
dc.contributor.author | Badiu, C | |
dc.contributor.author | Boschetti, M | |
dc.contributor.author | Ferone, D | |
dc.contributor.author | Ricci Bitti, S | |
dc.contributor.author | Brue, T | |
dc.contributor.author | Albarel, F | |
dc.contributor.author | Cannavò, S | |
dc.contributor.author | Cotta, OR | |
dc.contributor.author | Carvalho, D | |
dc.contributor.author | Salazar, D | |
dc.contributor.author | Christ, E | |
dc.contributor.author | Debono, M | |
dc.contributor.author | Dusek, T | |
dc.contributor.author | Garcia-Centeno, R | |
dc.contributor.author | Ghigo, E | |
dc.contributor.author | Gasco, V | |
dc.contributor.author | Góth, MI | |
dc.contributor.author | Oláh, D | |
dc.contributor.author | Kovacs, L | |
dc.contributor.author | Höybye, C | |
dc.contributor.author | Kocjan, T | |
dc.contributor.author | Mlekuš Kozamernik, K | |
dc.contributor.author | Kužma, M | |
dc.contributor.author | Payer, J | |
dc.contributor.author | Medic-Stojanoska, M | |
dc.contributor.author | Novak, A | |
dc.contributor.author | Miličević, T | |
dc.contributor.author | Pekic, S | |
dc.contributor.author | Miljic, D | |
dc.contributor.author | Perez Luis, J | |
dc.contributor.author | Pico, AM | |
dc.contributor.author | Preda, V | |
dc.contributor.author | Raverot, G | |
dc.contributor.author | Borson-Chazot, F | |
dc.contributor.author | Rochira, V | |
dc.contributor.author | Monzani, ML | |
dc.contributor.author | Sandahl, K | |
dc.contributor.author | Tsagarakis, S | |
dc.contributor.author | Mitravela, V | |
dc.contributor.author | Zacharieva, S | |
dc.contributor.author | Zilaitiene, B | |
dc.contributor.author | Verkauskiene, R | |
dc.date.accessioned | 2021-01-20T15:41:16Z | |
dc.date.available | 2021-01-20T15:41:16Z | |
dc.date.issued | 2020-12 | |
dc.identifier.citation | Martel-Duguech, L., Jorgensen, J., Korbonits, M., Johannsson, G., Webb, S., the ESE AGHD Study Group for a Pan-European audit, The ESE AGHD study Group, Adamidou, F, Mintziori, G, Arosio, M, Giavoli, C, Badiu, C, Boschetti, M, Ferone, D, Ricci Bitti, S, Brue, T, Albarel, F, Cannavo, S, Martino, G, Cotta, O R, Carvalho, D, Salazar, D, Christ, E, Debono, M, Dusek, T, García, R, Ghigo, E, Gasco, V, Goth, M I, Olah, D, Kovacs, L, Höybye, C, Kocjan, T, Mlekuš Kozamernik, K, Kužma, M, Medic Stojanoska, M, Novak, A, Miličević, T, Pekic, S, Milijic, D, Perez Luis, J, Pico, A, Preda, V, Raverot, G, Borson-Chazot, F, Rochira, V, Monzani, M L, Sandahl, K, Tsagarakis, S, Mitravela, V, Zacharieva, S, Zilatiene, B, & Verkauskiene, R. (2021). ESE audit on management of adult growth hormone deficiency in clinical practice, European Journal of Endocrinology, 184(2), 323-334. | en_US |
dc.identifier.issn | 0804-4643 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/69876 | |
dc.description.abstract | Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. Aims: 1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of healthcare professionals about AGHD. Design: On-line survey in endocrine centres throughout Europe. Patients&Methods: Endocrinologists voluntarily completed an electronic questionnaire regarding AGHD patients diagnosed or treated in 2017-2018. Results: Twenty-nine centres from 17 European countries and 1 from Australia participated, including 2148 AGHD patients, 28% of childhood-onset GHD. Aetiology was most frequently non-functioning pituitary adenoma (26%), craniopharyngioma (13%) and genetic/congenital mid-line malformations (13%). Diagnosis of GHD was confirmed by a stimulation test in 52% (GHRH+arginine, 44%; insulin-tolerance, 42%, glucagon, 7%; GHRH alone and clonidine tests, 7%); in the remaining, ≥3 pituitary deficiencies and low serum IGF-I were diagnostic. Initial GH dose was lower in older patients, but only women <26 years were prescribed a higher dose than men; dose titration was based on normal serum IGF-I, tolerance and side-effects. In one country, AGHD treatment was not approved. Full public reimbursement was not available in four countries and only in childhood-onset GHD in another. AGHD awareness was low among non-endocrine professionals and healthcare administrators. Postgraduate AGHD curriculum training deserves being improved. Conclusion: Despite guideline recommendations, GH replacement in AGHD is still not available or reimbursed in all European countries. Knowledge among professionals and health administrators needs improvement to optimize care of adults with GHD. | en_US |
dc.format.medium | Print-Electronic | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.relation.ispartof | European Journal of Endocrinology | |
dc.rights | “Disclaimer: this is not the definitive Version of Record of this article. This manuscript has been accepted for publication in European Journal of Endocrinology but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain.” "The definitive version is now freely available at https://doi.org/10.1530/EJE-20-1180 Feb 2021." | |
dc.title | ESE audit on management of adult growth hormone deficiency in clinical practice | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2021 The authors 2021 | |
dc.identifier.doi | 10.1530/eje-20-1180 | |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
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