Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
dc.contributor.author | Robertson, RC | en_US |
dc.contributor.author | Seira Oriach, C | en_US |
dc.contributor.author | Murphy, K | en_US |
dc.contributor.author | Moloney, GM | en_US |
dc.contributor.author | Cryan, JF | en_US |
dc.contributor.author | Dinan, TG | en_US |
dc.contributor.author | Paul Ross, R | en_US |
dc.contributor.author | Stanton, C | en_US |
dc.date.accessioned | 2021-01-12T15:42:27Z | |
dc.date.available | 2016-07-12 | en_US |
dc.date.available | 2021-01-12T15:42:27Z | |
dc.date.issued | 2017-01 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/69643 | |
dc.description.abstract | BACKGROUND: Neurodevelopment is strongly influenced by maternal and early-postnatal diet. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are vital structural and functional components of the developing brain. The gut microbiota is also influenced by n-3 PUFA status, however, little is known about the role of maternal and early-life n-3 PUFA intake on offspring gut microbiota development and subsequent interactions with central nervous system functioning and behavioural outcomes. METHODS: Pregnant female C57BL/6 mice and their male offspring were fed a control (CON), omega-3 deficient (O3-) or omega-3 supplemented (O3+) diet. Cognitive, depressive and social behaviours were assessed through a battery of behaviour tests in the male offspring at both adolescence (week 4-5) and adulthood (week 11-13). Hypothalamic-pituitary-adrenal axis (HPA) activation was assessed by analysis of stress-induced corticosterone production. Fecal microbiota composition was analysed by 16S sequencing at both adolescent and adulthood. In addition, stimulated spleen cytokine levels were assessed. RESULTS: n-3 PUFA interventions induced subtle changes in offspring early-life and adolescent behaviours, which were further evident in adulthood, such that O3- animals displayed impaired communication, social and depression-related behaviours and O3+ animals displayed enhanced cognition. O3- mice displayed an elevated Firmicutes:Bacteroidetes ratio and blunted systemic LPS responsiveness. Contrastingly, O3+ mice displayed greater fecal Bifidobacterium and Lactobacillus abundance and dampened HPA-axis activity. CONCLUSIONS: Neurobehavioural development related to cognitive, anxiety and social behaviours, is highly dependent upon in utero and lifelong n-3 PUFA availability. In addition, neurobehavioural changes induced by altering n-3 PUFA status are closely associated with comprehensive alterations in gut microbiota composition, HPA-axis activity and inflammation. | en_US |
dc.format.extent | 21 - 37 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Brain Behav Immun | en_US |
dc.subject | Adolescence | en_US |
dc.subject | Behaviour | en_US |
dc.subject | Cognition | en_US |
dc.subject | Corticosterone | en_US |
dc.subject | Depression | en_US |
dc.subject | Diet | en_US |
dc.subject | Gut-brain axis | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Microbiota | en_US |
dc.subject | Neurodevelopment | en_US |
dc.subject | Omega-3 polyunsaturated fatty acids | en_US |
dc.subject | Psychiatric illnesses | en_US |
dc.subject | Social behaviour | en_US |
dc.subject | Aging | en_US |
dc.subject | Animals | en_US |
dc.subject | Behavior, Animal | en_US |
dc.subject | Cognition | en_US |
dc.subject | Corticosterone | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Depression | en_US |
dc.subject | Fatty Acids | en_US |
dc.subject | Fatty Acids, Omega-3 | en_US |
dc.subject | Fear | en_US |
dc.subject | Female | en_US |
dc.subject | Gastrointestinal Microbiome | en_US |
dc.subject | Hypothalamo-Hypophyseal System | en_US |
dc.subject | Male | en_US |
dc.subject | Mice | en_US |
dc.subject | Mice, Inbred C57BL | en_US |
dc.subject | Pituitary-Adrenal System | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Recognition, Psychology | en_US |
dc.subject | Social Behavior | en_US |
dc.subject | Stress, Psychological | en_US |
dc.subject | Swimming | en_US |
dc.subject | Vocalization, Animal | en_US |
dc.title | Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1016/j.bbi.2016.07.145 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/27423492 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 59 | en_US |
dcterms.dateAccepted | 2016-07-12 | en_US |
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