• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Survival mechanisms in B lymphoid malignancies and associated therapies 
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Survival mechanisms in B lymphoid malignancies and associated therapies
    •   QMRO Home
    • Queen Mary University of London Theses
    • Theses
    • Survival mechanisms in B lymphoid malignancies and associated therapies
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Survival mechanisms in B lymphoid malignancies and associated therapies

    View/Open
    SUSurvivalMechanisms2011.pdf (6.062Mb)
    Publisher
    Queen Mary University of London
    Metadata
    Show full item record
    Abstract
    The apoptotic pathway plays critical roles in regulating lymphocyte survival throughout B cell development, maturation and differentiation. The whole process involves clonal expansion. In the normal B lymphocyte population the majority of cells and their progenitors derived from each stage die from induction of apoptosis under specific mechanisms of control. Failure to do so can result in malignant transformation. This project focuses on apoptotic pathways and associated survival mechanisms in neoplasms of lymphoid provenance with an emphasis on B cell malignancies. The role of galectin-3, a molecule implicated in signal transduction and apoptotic pathways, has been investigated in both primary CLL cells and cell lines of human B lineage, using GCS-100, a novel galectin-3 antagonist. The potential interaction between galectin-3 and Bcl-2 and its contribution to cell death have been explored in depth. The role of NADPH oxidase and ROS in mitochondria has also been examined in the context of apoptosis. PK11195, a small proapoptotic molecule, has been studied in relation to mitochondria-mediated apoptosis. The above investigations could contribute to a rationale for potential novel strategies in the treatment of B cell malignancies.
    Authors
    Su, Bo
    URI
    https://qmro.qmul.ac.uk/xmlui/handle/123456789/685
    Collections
    • Theses [3822]
    Copyright statements
    The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the author
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.