The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa.
dc.contributor.author | Churcher, TS | en_US |
dc.contributor.author | Lissenden, N | en_US |
dc.contributor.author | Griffin, JT | en_US |
dc.contributor.author | Worrall, E | en_US |
dc.contributor.author | Ranson, H | en_US |
dc.date.accessioned | 2020-10-01T09:18:35Z | |
dc.date.available | 2016-08-18 | en_US |
dc.date.issued | 2016-08-22 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/67339 | |
dc.description.abstract | Long lasting pyrethroid treated bednets are the most important tool for preventing malaria. Pyrethroid resistant Anopheline mosquitoes are now ubiquitous in Africa, though the public health impact remains unclear, impeding the deployment of more expensive nets. Meta-analyses of bioassay studies and experimental hut trials are used to characterise how pyrethroid resistance changes the efficacy of standard bednets, and those containing the synergist piperonyl butoxide (PBO), and assess its impact on malaria control. New bednets provide substantial personal protection until high levels of resistance, though protection may wane faster against more resistant mosquito populations as nets age. Transmission dynamics models indicate that even low levels of resistance would increase the incidence of malaria due to reduced mosquito mortality and lower overall community protection over the life-time of the net. Switching to PBO bednets could avert up to 0.5 clinical cases per person per year in some resistance scenarios. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Elife | en_US |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | P. falciparum | en_US |
dc.subject | bednets | en_US |
dc.subject | epidemiology | en_US |
dc.subject | global health | en_US |
dc.subject | malaria | en_US |
dc.subject | mosquito | en_US |
dc.subject | pyrethroid resistance | en_US |
dc.subject | Africa | en_US |
dc.subject | Animals | en_US |
dc.subject | Anopheles | en_US |
dc.subject | Biological Assay | en_US |
dc.subject | Humans | en_US |
dc.subject | Insecticide Resistance | en_US |
dc.subject | Insecticide-Treated Bednets | en_US |
dc.subject | Insecticides | en_US |
dc.subject | Malaria | en_US |
dc.subject | Models, Statistical | en_US |
dc.subject | Mosquito Control | en_US |
dc.subject | Mosquito Vectors | en_US |
dc.subject | Nitriles | en_US |
dc.subject | Permethrin | en_US |
dc.subject | Pesticide Synergists | en_US |
dc.subject | Piperonyl Butoxide | en_US |
dc.subject | Pyrethrins | en_US |
dc.title | The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa. | en_US |
dc.type | Article | |
dc.rights.holder | © 2020 the Author(s) | |
dc.identifier.doi | 10.7554/eLife.16090 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/27547988 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 5 | en_US |
dcterms.dateAccepted | 2016-08-18 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Synthesising data from multiple spatial scales and levels of detail to improve malaria transmission model predictions::Medical Research Council (MRC) | en_US |
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Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.