dc.contributor.author | O'Toole, SM | en_US |
dc.contributor.author | Sze, W-CC | en_US |
dc.contributor.author | Chung, T-T | en_US |
dc.contributor.author | Akker, SA | en_US |
dc.contributor.author | Druce, MR | en_US |
dc.contributor.author | Waterhouse, M | en_US |
dc.contributor.author | Pitkin, S | en_US |
dc.contributor.author | Dawnay, A | en_US |
dc.contributor.author | Sahdev, A | en_US |
dc.contributor.author | Matson, M | en_US |
dc.contributor.author | Parvanta, L | en_US |
dc.contributor.author | Drake, WM | en_US |
dc.date.accessioned | 2020-08-21T15:21:30Z | |
dc.date.available | 2020-08-05 | en_US |
dc.date.issued | 2020-10-01 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/66512 | |
dc.description | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Clinical Endocrinology and Metabolism following peer review. The version of record: Samuel Matthew O’Toole, Wing-Chiu Candy Sze, Teng-Teng Chung, Scott Alexander Akker, Maralyn Rose Druce, Mona Waterhouse, Sarah Pitkin, Anne Dawnay, Anju Sahdev, Matthew Matson, Laila Parvanta, William Martyn Drake, Low grade cortisol co-secretion has limited impact on ACTH-stimulated AVS parameters in primary aldosteronism, The Journal of Clinical Endocrinology & Metabolism, dgaa519, https://doi.org/10.1210/clinem/dgaa519 | en_US |
dc.description.abstract | CONTEXT: In primary aldosteronism, cosecretion of cortisol may alter cortisol-derived adrenal venous sampling indices. OBJECTIVE: To identify whether cortisol cosecretion in primary aldosteronism alters adrenal venous sampling parameters and interpretation. DESIGN: Retrospective case-control study. SETTING: A tertiary referral center. PATIENTS: 144 adult patients with primary aldosteronism who had undergone both adrenocorticotropic hormone-stimulated adrenal venous sampling and dexamethasone suppression testing between 2004 and 2018. MAIN OUTCOME MEASURES: Adrenal venous sampling indices including adrenal vein aldosterone/cortisol ratios and the selectivity, lateralization, and contralateral suppression indices. RESULTS: 21 (14.6%) patients had evidence of cortisol cosecretion (defined as a failure to suppress cortisol to ≤50 nmol/L post dexamethasone). Patients with evidence of cortisol cosecretion had a higher inferior vena cava cortisol concentration (P = .01) than those without. No difference was observed between the groups in terms of selectivity index, lateralization index, lateralization of aldosterone excess, or adrenal vein cannulation rate. CONCLUSIONS: Cortisol cosecretion alters some parameters in adrenocorticotrophic hormone-stimulated adrenal venous sampling but does not result in alterations in patient management. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | J Clin Endocrinol Metab | en_US |
dc.subject | primary aldosteronism | en_US |
dc.subject | adrenal venous sampling | en_US |
dc.subject | adrenalectomy | en_US |
dc.subject | cortisol | en_US |
dc.subject | cortisol co-secretion | en_US |
dc.title | Low-grade Cortisol Cosecretion Has Limited Impact on ACTH-stimulated AVS Parameters in Primary Aldosteronism. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1210/clinem/dgaa519 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/32785656 | en_US |
pubs.issue | 10 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 105 | en_US |
dcterms.dateAccepted | 2020-08-05 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |