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dc.contributor.authorXIAO, Qen_US
dc.contributor.authorMandal, Ken_US
dc.contributor.authorSchett, Gen_US
dc.contributor.authorMayr, Men_US
dc.contributor.authorWick, Gen_US
dc.contributor.authorOberhollenzer, Fen_US
dc.contributor.authorWilleit, Jen_US
dc.contributor.authorKiechl, Sen_US
dc.contributor.authorXU, Qen_US
dc.date.accessioned2015-02-23T11:58:13Z
dc.date.issued2005-10-27en_US
dc.identifier.issn0039-2499en_US
dc.identifier.otherPMID: 16254226
dc.identifier.otherPMID: 16254226
dc.identifier.otherPMID: 16254226
dc.identifier.otherPMID: 16254226en_US
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/6621
dc.description.abstractBACKGROUND AND PURPOSE: Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis. In the current evaluation, we tested the hypothesis that sHSP60 levels are associated with the progression of carotid arteriosclerosis, prospectively. METHODS: The association of sHSP60 with early atherogenesis (5-year development and progression of nonstenotic carotid plaques) was investigated as part of the population-based prospective Bruneck Study. The current study focused on the follow-up period between 1995 and 2000 and, thus, included 684 subjects. RESULTS: sHSP60 levels measured in 1995 and 2000 were highly correlated (r=0.40; P<0.001), indicating consistency over a 5-year period. Circulating HSP60 levels were significantly correlated with antilipopolysaccharide and anti-HSP60 antibodies. It was also elevated in subjects with chronic infection (top quintile group of HSP60, among subjects with and without chronic infection: 23.8% versus 17.0%; P=0.003 after adjustment for age and sex). HSP60 levels were significantly associated with early atherogenesis, both in the entire population (multivariate odds ratio, for a comparison between quintile group V versus I+II: 2.0 [1.2 to 3.5] and the subgroup free of atherosclerosis at the 1995 baseline: 3.8 [1.6 to 8.9]). The risk of early atherogenesis was additionally amplified when high-sHSP60 and chronic infection were present together. CONCLUSIONS: Our study provides the first prospective data confirming an association between high levels of sHSP60 and early carotid atherosclerosis. This possibly indicates an involvement of sHSP60 in activating proinflammatory processes associated with early vessel pathology.en_US
dc.format.extent2571 - 2576 (6)en_US
dc.languageENGLISHen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofStrokeen_US
dc.titleAssociation of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up studyen_US
dc.typeArticle
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.publisher-urlhttp://www.lww.com/en_US
pubs.volume36en_US


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