dc.contributor.author | Fernández-Avilés, F | |
dc.contributor.author | Sanz-Ruiz, R | |
dc.contributor.author | Climent, AM | |
dc.contributor.author | Badimon, L | |
dc.contributor.author | Bolli, R | |
dc.contributor.author | Charron, D | |
dc.contributor.author | Fuster, V | |
dc.contributor.author | Janssens, S | |
dc.contributor.author | Kastrup, J | |
dc.contributor.author | Kim, H-S | |
dc.contributor.author | Lüscher, TF | |
dc.contributor.author | Martin, JF | |
dc.contributor.author | Menasché, P | |
dc.contributor.author | Simari, RD | |
dc.contributor.author | Stone, GW | |
dc.contributor.author | Terzic, A | |
dc.contributor.author | Willerson, JT | |
dc.contributor.author | Wu, JC | |
dc.contributor.author | TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) Writing Group | |
dc.contributor.author | Authors/Task Force Members. Chairpersons | |
dc.contributor.author | Basic Research Subcommittee | |
dc.contributor.author | Translational Research Subcommittee | |
dc.contributor.author | Challenges of Cardiovascular Regenerative Medicine Subcommittee | |
dc.contributor.author | Tissue Engineering Subcommittee | |
dc.contributor.author | Delivery, Navigation, Tracking and Assessment Subcommittee | |
dc.contributor.author | Clinical Trials Subcommittee | |
dc.contributor.author | Regulatory and funding strategies subcommittee | |
dc.contributor.author | Delivery, Navigation, Tracking and Assessment Subcommittee | |
dc.date.accessioned | 2020-07-03T13:54:40Z | |
dc.date.available | 2017-04-20 | |
dc.date.available | 2020-07-03T13:54:40Z | |
dc.date.issued | 2017-05-30 | |
dc.identifier.citation | Fernández-Avilés F, Sanz-Ruiz R, Climent AM, et al. Global position paper on cardiovascular regenerative medicine [published correction appears in Eur Heart J. 2018 May 14;39(19):1723]. Eur Heart J. 2017;38(33):2532-2546. doi:10.1093/eurheartj/ehx248 | en_US |
dc.identifier.issn | 0195-668X | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/65447 | |
dc.description.abstract | Based on the increasingly understood regenerative capacity of the human heart and vascular system,1 cardiovascular regenerative medicine (CRM) encompasses all potential diagnostic and therapeutic strategies aimed at restoring organ health. Envisioned to enhance the innate regenerative response of cardiovascular tissues, diverse and often complementary products and strategies have been investigated (e.g. stem and progenitor cells, stromal cells, extracellular vesicles such as microvesicles and exosomes, growth factors, non-coding RNAs, episomes and other gene therapies, biomaterials, tissue engineering products, and neo-organogenesis). Despite promising results based on 20 years of research, next generation CRM treatments have yet to transform cardiovascular practice.
Given the compelling need for a thorough critical debate on the past, present, and future of CRM, the international consortium Transnational AllianCe for regenerative Therapies In Cardiovascular Syndromes (TACTICS, www.tacticsalliance.org)2 summarizes the shared vision of leading expert teams in the field (for a complete list of TACTICS members please see Annex 1). The document addresses key priorities and challenges, including basic and translational research, clinical practice, regulatory hurdles, and funding sources. The methodological procedure included the following: (i) identification of strengths, weaknesses, opportunities, and threats (SWOT analysis) by means of an open poll; (ii) distribution of the main topics between at least two worldwide key opinion leaders, who prepared proposals for each topic; (iii) open discussion and consensus on each proposal between all members of TACTICS; and (iv) review of the document by an independent committee. | en_US |
dc.description.sponsorship | Spanish Ministry of Economy through the Instituto de Salud Carlos III-FEDER (Fondo Europeo de Desarrollo Regional) (PLE2009-0152, IJCI-2014-22178, PI13-01882, SAF2016-76819-R, CPII15/00017), the Red de Investigación Cardiovacular (RIC. RD12.0042.0001) and the Red of Terapia Celular (TERCEL. RD12.0019.0021, RD16/00110018 and CB16/11/0041); FEDER ‘Una Manera de Hacer Europa’; and ‘CERCA Programme/Generalitat de Catalunya’ Spain (in part); BAMI (7th FP); SCIENCE (Horizon 2020), Pegasus, Circulate (STRATEGMED by Polish Natinal Centre for Research and Development), statutory funds Medical University of Silesia; NIH and the Mayo Foundation. Netherlands CardioVascular Research Initiative (CVON): The Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Science. Academy of Finland. National Institutes of Health (R01HL084275, R01HL107110, UM1HL113460, and R01HL110737); Starr and Soffer Family Foundations; HLA&MEDECINE.NIH (R01HL067245, R37HL091102, R01HL105759, R01HL113647, R01HL117163, P01HL085577, R01HL122525, P01 HL-78825, and 1 UM1 HL-113530 (CCTRN)) (in part). A.T. reports research grants, administered by Mayo Clinic, from Marriott Foundation, Michael S. and Mary Sue Shannon Family, Russ and Kathy VanCleve Foundation, Leducq Foundation, Florida Heart Research Institute, Celyad, and National Institutes of Health. Ministerio de Educaciœn Ciencia (SAF2014-59892), Fundaciœ MARATÓ de TV3 (201502, 201516), Red de Terapia Celular - TerCel (RD16/0011/0006) and CIBER Cardiovascular (CB16/11/00403) as part of the Plan Nacional de I+D+I, and AdvanceCat 2014-2020 to A.B.G. | en_US |
dc.format.extent | 2532 - 2546 | |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | Eur Heart J | |
dc.rights | CC-NC | |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject | Cardiovascular Diseases | en_US |
dc.subject | Consensus | en_US |
dc.subject | Humans | en_US |
dc.subject | Precision Medicine | en_US |
dc.subject | Regenerative Medicine | en_US |
dc.title | Global position paper on cardiovascular regenerative medicine. | en_US |
dc.type | Article | en_US |
dc.rights.holder | 2017. The authors | |
dc.identifier.doi | 10.1093/eurheartj/ehx248 | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28575280 | en_US |
pubs.issue | 33 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 38 | en_US |
dcterms.dateAccepted | 2017-04-20 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |