dc.contributor.author | Mariniello, K | |
dc.contributor.author | Ruiz-Babot, G | |
dc.contributor.author | McGaugh, EC | |
dc.contributor.author | Nicholson, JG | |
dc.contributor.author | Gualtieri, A | |
dc.contributor.author | Gaston-Massuet, C | |
dc.contributor.author | Nostro, MC | |
dc.contributor.author | Guasti, L | |
dc.date.accessioned | 2020-06-09T13:23:20Z | |
dc.date.available | 2019-10-23 | |
dc.date.available | 2020-06-09T13:23:20Z | |
dc.date.issued | 2019-11-08 | |
dc.identifier.citation | Mariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC and Guasti L (2019) Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System. Front. Endocrinol. 10:772. doi: 10.3389/fendo.2019.00772 | en_US |
dc.identifier.issn | 1664-2392 | |
dc.identifier.other | ARTN 772 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64750 | |
dc.description.abstract | The endocrine system coordinates a wide array of body functions mainly through secretion of hormones and their actions on target tissues. Over the last decades, a collective effort between developmental biologists, geneticists, and stem cell biologists has generated a wealth of knowledge related to the contribution of stem/progenitor cells to both organogenesis and self-renewal of endocrine organs. This review provides an up-to-date and comprehensive overview of the role of tissue stem cells in the development and self-renewal of endocrine organs. Pathways governing crucial steps in both development and stemness maintenance, and that are known to be frequently altered in a wide array of endocrine disorders, including cancer, are also described. Crucially, this plethora of information is being channeled into the development of potential new cell-based treatment modalities for endocrine-related illnesses, some of which have made it through clinical trials. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.relation.ispartof | FRONTIERS IN ENDOCRINOLOGY | |
dc.rights | Creative Commons Attribution License (CC BY) | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | stem cells | en_US |
dc.subject | development | en_US |
dc.subject | self-renewal | en_US |
dc.subject | regenerative medicine | en_US |
dc.subject | plasticity | en_US |
dc.title | Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System | en_US |
dc.type | Article | en_US |
dc.rights.holder | © 2019 Mariniello, Ruiz-Babot, McGaugh, Nicholson, Gualtieri, Gaston-Massuet, Nostro and Guasti. | |
dc.identifier.doi | 10.3389/fendo.2019.00772 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000498994500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 10 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | 8) Lineage conversion of blood-derived endothelial progenitor cells to an adrenocortical phenotype: a new tool to study the adrenal gland::Biotechnology and Biological Sciences Research Council | en_US |
qmul.funder | 8) Lineage conversion of blood-derived endothelial progenitor cells to an adrenocortical phenotype: a new tool to study the adrenal gland::Biotechnology and Biological Sciences Research Council | en_US |
qmul.funder | 8) Lineage conversion of blood-derived endothelial progenitor cells to an adrenocortical phenotype: a new tool to study the adrenal gland::Biotechnology and Biological Sciences Research Council | en_US |
qmul.funder | 8) Lineage conversion of blood-derived endothelial progenitor cells to an adrenocortical phenotype: a new tool to study the adrenal gland::Biotechnology and Biological Sciences Research Council | en_US |