Model-based evolutionary analysis: the natural history of phage-shock stress response
Volume
37
Pagination
762 - 767
Publisher
DOI
10.1042/bst0370762
Journal
Biochemical Society Transactions
Issue
ISSN
0300-5127
Metadata
Show full item recordAbstract
<jats:p>The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.</jats:p>