Centre for Clinical Trials & Methodology: Recent submissions
Now showing items 41-60 of 263
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A feasibility trial of a digital mindfulness-based intervention to improve asthma-related quality of life for primary care patients with asthma.
(2022-02)Asthma outcomes remain suboptimal, despite effective pharmacotherapy. Psychological dysfunction (such as anxiety) is common, and associated with poorer outcomes. We evaluated a digital mindfulness programme as an intervention ... -
Understanding GPs' views and experiences of using clinical prediction rules in the management of respiratory infections: a qualitative study.
(2021-08)BACKGROUND: Respiratory tract infections (RTIs) account for 60% of antibiotic prescribing in primary care. Several clinical prediction rules (CPRs) have been developed to help reduce unnecessary prescribing for RTIs, but ... -
Patient-reported outcome measures for acne: a mixed-methods validation study (acne PROMs).
(2021-03-19)OBJECTIVES: To examine the acceptability and validity of two patient-reported outcome measures (PROMs) for adult acne, comparing them to the validated Acne-specific Quality of Life (Acne-QoL) measure. DESIGN: Mixed-methods ... -
Physical Activity, Mental Health and Wellbeing of Adults within and during the Easing of COVID-19 Restrictions, in the United Kingdom and New Zealand.
(2022-02-04)Physical activity (PA) participation was substantially reduced at the start of the COVID-19 pandemic. The purpose of this study was to assess the association between PA, mental health, and wellbeing during and following ... -
Planning and developing a web-based intervention for active surveillance in prostate cancer: an integrated self-care programme for managing psychological distress.
(2022-08-09)OBJECTIVES: To outline the planning, development and optimisation of a psycho-educational behavioural intervention for patients on active surveillance for prostate cancer. The intervention aimed to support men manage active ... -
Nonlinear effects and effect modification at the participant-level in IPD meta-analysis part 1: analysis methods are often substandard.
(2023-05-04)OBJECTIVES: To review analysis methods used for linear effect modification (LEM), nonlinear covariate-outcome associations (NL) and nonlinear effect modification (NLEM) at the participant-level in individual participant ... -
Postal methods for monitoring HbA1c in diabetes mellitus: a protocol for systematic review.
(2022-12)BACKGROUND: Worldwide there are an estimated 463 million people with diabetes. In the UK people with diabetes are offered annual review, which includes monitoring of haemoglobin A1c (HbA1c). This can identify people with ... -
Role of breast MRI in screening women with dense breasts: A systematic review
(Elsevier, 2023-05) -
Hypofractionation: The standard for external beam breast irradiation.
(2023-06)This overview provides the historical perspective of external beam breast hypofractionation over the last 50 years. It highlights the serious harm suffered by patients with breast cancer in the 1970's and 1980's because ... -
Supporting Self-management Among Young People With Acne Vulgaris Through a Web-Based Behavioral Intervention: Development and Feasibility Randomized Controlled Trial.
(2021-11-03)BACKGROUND: Acne is a common skin condition that is most prevalent in young people. It can have a substantial impact on the quality of life, which can be minimized with the appropriate use of topical treatments. Nonadherence ... -
Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.
(2020-11-11)BACKGROUND: The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema clinical trials. Previous consensus meetings have agreed upon preferred instruments ...