Browsing Centre for Clinical Trials & Methodology by Title
Now showing items 86-105 of 263
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EQ-5D-5L Health-State Values for the Mexican Population.
(2021-06-26)OBJECTIVE: To generate a value set for the Mexican adult general population to support and facilitate the inclusion of quality-adjusted life years (QALYs) into the health technology assessment process of the Mexican ... -
The EQ-5D-5L Value Set for England: Response to the “Quality Assurance”
(Elsevier BV, 2020-03) -
ESCP Safe Anastomosis ProGramme in CoLorectal SurgEry (EAGLE): Study protocol for an international cluster randomised trial of a quality improvement intervention to reduce anastomotic leak following right colectomy.
(Wiley, 2021-07-13)AIM: Cohort data suggest that anastomotic leak occurs after 8% of right colectomies causing significant morbidity and mortality. Patient selection, intra-operative factors, and technical variation all contribute to risk ... -
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
(2023-11-29)BACKGROUND: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality ... -
External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis.
(2020-11-02)BACKGROUND: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published ... -
Facedown Positioning Following Surgery for Large Full-Thickness Macular Hole: A Multicenter Randomized Clinical Trial.
(American Medical Association, 2020-05-07)Importance: The value of facedown positioning following surgery for large full-thickness macular holes is unknown. Objective: To determine whether advice to position facedown postoperatively improves the outcome for large ... -
A feasibility trial of a digital mindfulness-based intervention to improve asthma-related quality of life for primary care patients with asthma.
(2022-02)Asthma outcomes remain suboptimal, despite effective pharmacotherapy. Psychological dysfunction (such as anxiety) is common, and associated with poorer outcomes. We evaluated a digital mindfulness programme as an intervention ... -
FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study.
(2022-10-18)BACKGROUND: Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate ... -
Four decades of measuring stillbirths and neonatal deaths in Demographic and Health Surveys: historical review
(Springer Science and Business Media LLC, 2021-02-08)Background Worldwide, an estimated 5.1 million stillbirths and neonatal deaths occur annually, 98% in low- and middle-income countries. Limited coverage of civil and vital registration systems necessitates reliance on ... -
Fresh street: the development and feasibility of a place-based, subsidy for fresh fruit and vegetables.
(Oxford University Press (OUP), 2020-11-09)BACKGROUND: Many UK communities experience food insecurity, and consume diets high in energy-dense, nutrient poor, processed foods and low in fruit and vegetables (FV). We explored a novel area-based approach to promote ... -
Gestational age data completeness, quality and validity in population-based surveys: EN-INDEPTH study.
(BMC part of Springer Nature, 2021-02-08)BACKGROUND: Preterm birth (gestational age (GA) <37 weeks) is the leading cause of child mortality worldwide. However, GA is rarely assessed in population-based surveys, the major data source in low/middle-income countries. ...