Browsing Centre for Clinical Trials & Methodology by Title
Now showing items 220-239 of 263
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Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCT
(2019-02-01)Background Sperm selection for intracytoplasmic sperm injection (ICSI) has traditionally relied on standardised methods of sperm processing combined with subjective sperm selection (motility/morphology). In 2012, live birth ... -
The staircase cluster randomised trial design: A pragmatic alternative to the stepped wedge.
(2023-11-30)This article introduces the 'staircase' design, derived from the zigzag pattern of steps along the diagonal of a stepped wedge design schematic where clusters switch from control to intervention conditions. Unlike a complete ... -
Statistical analysis plan for the Early Youth Engagement in first episode psychosis (EYE-2) study: a pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement.
(2021-10-23)BACKGROUND: Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium-long term, but 25% of young people disengage in the first 12 months with costs to their mental ... -
Stillbirth maternity care measurement and associated factors in population-based surveys: EN-INDEPTH study.
(BMC part of Springer Nature, 2021-02-08)BACKGROUND: Household surveys remain important sources of maternal and child health data, but until now, standard surveys such as Demographic and Health Surveys (DHS) have not collected information on maternity care for ... -
Stillbirth outcome capture and classification in population-based surveys: EN-INDEPTH study.
(BMC part of Springer Nature, 2021-02-08)BACKGROUND: Household surveys remain important sources of stillbirth data, but omission and misclassification are common. Classifying adverse pregnancy outcomes as stillbirths requires accurate reporting of vital status ... -
Stillbirths including intrapartum timing: EN-BIRTH multi-country validation study.
(BioMed Central, 2021-03-26)BACKGROUND: An estimated >2 million babies stillborn around the world each year lack visibility. Low- and middle-income countries carry 84% of the burden yet have the least data. Most births are now in facilities, hence ... -
Study within a trial of electronic versus paper-based Patient-Reported oUtcomes CollEction (SPRUCE): study protocol for a partially randomised patient preference study.
(2023-09-21)INTRODUCTION: Patient-reported outcomes (PRO) are currently collected from trial participants using paper questionnaires by the Clinical Trials and Statistics Unit at The Institute of Cancer Research (ICR-CTSU). Streamlining ... -
Supported accommodation for people with mental health problems: the QuEST research programme with feasibility RCT
<jats:sec id="abs1-1"> <jats:title>Background</jats:title> <jats:p>Across England, around 60,000 people live in mental health supported accommodation: residential care, supported housing and floating outreach. Residential ... -
Supporting Self-management Among Young People With Acne Vulgaris Through a Web-Based Behavioral Intervention: Development and Feasibility Randomized Controlled Trial.
(2021-11-03)BACKGROUND: Acne is a common skin condition that is most prevalent in young people. It can have a substantial impact on the quality of life, which can be minimized with the appropriate use of topical treatments. Nonadherence ... -
Survey of women's report for 33 maternal and newborn indicators: EN-BIRTH multi-country validation study.
(2021-03-26)BACKGROUND: Population-based household surveys, notably the Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS), remain the main source of maternal and newborn health data for many low- and ... -
Synergism and rules from combination of Baicalin, Jasminoidin and Desoxycholic acid in refined Qing Kai Ling for treat ischemic stroke mice model.
(Public Library of Science, 2012-09-26)Refined Qing-Kai-Ling (QKL), a modified Chinese medicine, consists of three main ingredients (Baicalin, Jasminoidin and Desoxycholic acid), plays a synergistic effect on the treatment of the acute stage of ischemic stroke. ... -
Systematic review of clinical practice guidelines for acne vulgaris published between January 2017 and July 2021.
(2023-08)BACKGROUND: Acne is very common, can cause considerable negative impact on quality of life and there is increasing concern over the use of long courses of oral antibiotics for this condition. OBJECTIVES: (1) To critically ...