Browsing Centre for Clinical Trials & Methodology by Title
Now showing items 158-177 of 263
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Nonlinear effects and effect modification at the participant-level in IPD meta-analysis part 1: analysis methods are often substandard.
(2023-05-04)OBJECTIVES: To review analysis methods used for linear effect modification (LEM), nonlinear covariate-outcome associations (NL) and nonlinear effect modification (NLEM) at the participant-level in individual participant ... -
One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: the FAST-Forward phase III RCT.
(2023-11)BACKGROUND: FAST-Forward aimed to identify a 5-fraction schedule of adjuvant radiotherapy delivered in 1 week that was non-inferior in terms of local cancer control and as safe as the standard 15-fraction regimen after ... -
One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: the FAST-Forward phase III RCT.
(NIHR Journals Library, 2023-11-21) -
An optimization framework to guide the choice of thresholds for risk-based cancer screening.
(2023-11-28)It is uncommon for risk groups defined by statistical or artificial intelligence (AI) models to be chosen by jointly considering model performance and potential interventions available. We develop a framework to rapidly ... -
Paradata analyses to inform population-based survey capture of pregnancy outcomes: EN-INDEPTH study
(BioMed Central, 2021-02-08)Background: Paradata are (timestamped) records tracking the process of (electronic) data collection. We analysed paradata from a large household survey of questions capturing pregnancy outcomes to assess performance ... -
Patient-reported outcome measures for acne: a mixed-methods validation study (acne PROMs).
(2021-03-19)OBJECTIVES: To examine the acceptability and validity of two patient-reported outcome measures (PROMs) for adult acne, comparing them to the validated Acne-specific Quality of Life (Acne-QoL) measure. DESIGN: Mixed-methods ... -
Patients' costs, socio-economic and health system aspects associated with malaria in pregnancy in an endemic area of Colombia.
(2018-05)Malaria in pregnancy threatens birth outcomes and the health of women and their newborns. This is also the case in low transmission areas, such as Colombia, where Plasmodium vivax is the dominant parasite species. Within ... -
Physical Activity, Mental Health and Wellbeing of Adults within and during the Easing of COVID-19 Restrictions, in the United Kingdom and New Zealand.
(2022-02-04)Physical activity (PA) participation was substantially reduced at the start of the COVID-19 pandemic. The purpose of this study was to assess the association between PA, mental health, and wellbeing during and following ... -
Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty.
(2021-07-03)BACKGROUND AND OBJECTIVE: Feasibility studies are increasingly being used to support the development of, and investigate uncertainties around, future large-scale trials. The future trial can be designed with either a ... -
Planning and developing a web-based intervention for active surveillance in prostate cancer: an integrated self-care programme for managing psychological distress.
(2022-08-09)OBJECTIVES: To outline the planning, development and optimisation of a psycho-educational behavioural intervention for patients on active surveillance for prostate cancer. The intervention aimed to support men manage active ...