dc.contributor.author | Rylance, S | en_US |
dc.contributor.author | Nightingale, R | en_US |
dc.contributor.author | Naunje, A | en_US |
dc.contributor.author | Mbalume, F | en_US |
dc.contributor.author | Jewell, C | en_US |
dc.contributor.author | Balmes, JR | en_US |
dc.contributor.author | Grigg, J | en_US |
dc.contributor.author | Mortimer, K | en_US |
dc.date.accessioned | 2020-03-03T16:15:05Z | |
dc.date.available | 2019-06-01 | en_US |
dc.date.issued | 2019-11 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/63011 | |
dc.description.abstract | BACKGROUND: Non-communicable lung disease and exposure to air pollution are major problems in sub-Saharan Africa. A high burden of chronic respiratory symptoms, spirometric abnormalities and air pollution exposures has been found in Malawian adults; whether the same would be true in children is unknown. METHODS: This cross-sectional study of children aged 6-8 years, in rural Malawi, included households from communities participating in the Cooking and Pneumonia Study (CAPS), a trial of cleaner-burning biomass-fuelled cookstoves. We assessed; chronic respiratory symptoms, anthropometry, spirometric abnormalities (using Global Lung Initiative equations) and personal carbon monoxide (CO) exposure. Prevalence estimates were calculated, and multivariable analyses were done. RESULTS: We recruited 804 children (mean age 7.1 years, 51.9% female), including 476 (260 intervention; 216 control) from CAPS households. Chronic respiratory symptoms (mainly cough (8.0%) and wheeze (7.1%)) were reported by 16.6% of children. Average height-for-age and weight-for-age z-scores were -1.04 and -1.10, respectively. Spirometric abnormalities (7.1% low forced vital capacity (FVC); 6.3% obstruction) were seen in 13.0% of children. Maximum CO exposure and carboxyhaemoglobin levels (COHb) exceeded WHO guidelines in 50.1% and 68.5% of children, respectively. Children from CAPS intervention households had lower COHb (median 3.50% vs 4.85%, p=0.006) and higher FVC z-scores (-0.22 vs -0.44, p=0.05) than controls. CONCLUSION: The substantial burden of chronic respiratory symptoms, abnormal spirometry and air pollution exposures in children in rural Malawi is concerning; effective prevention and control strategies are needed. Our finding of potential benefit in CAPS intervention households calls for further research into clean-air interventions to maximise healthy lung development in children. | en_US |
dc.format.extent | 1070 - 1077 | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Thorax | en_US |
dc.rights | Creative Commons Attribution 4.0 Unported (CC BY 4.0) license | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | asthma epidemiology | en_US |
dc.subject | lung physiology | en_US |
dc.subject | paediatric asthma | en_US |
dc.subject | paediatric lung disaese | en_US |
dc.title | Lung health and exposure to air pollution in Malawian children (CAPS): a cross-sectional study. | en_US |
dc.type | Article | |
dc.rights.holder | © Author(s) (or their employer(s)) 2019. | |
dc.identifier.doi | 10.1136/thoraxjnl-2018-212945 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31467192 | en_US |
pubs.issue | 11 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 74 | en_US |
dcterms.dateAccepted | 2019-06-01 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |
qmul.funder | Advanced cookstove intervention to prevent pneumonia in Children under 5 in Malawi::Medical Research Council | en_US |