dc.contributor.author | Molina-Montes, E | |
dc.contributor.author | Gomez-Rubio, P | |
dc.contributor.author | Marquez, M | |
dc.contributor.author | Rava, M | |
dc.contributor.author | Lohr, M | |
dc.contributor.author | Michalski, CW | |
dc.contributor.author | Molero, X | |
dc.contributor.author | Farre, A | |
dc.contributor.author | Perea, J | |
dc.contributor.author | Greenhalf, W | |
dc.contributor.author | Ilzarbe, L | |
dc.contributor.author | O'Rorke, M | |
dc.contributor.author | Tardon, A | |
dc.contributor.author | Gress, T | |
dc.contributor.author | Barbera, VM | |
dc.contributor.author | Crnogorac-Jurcevic, T | |
dc.contributor.author | Dominguez-Munoz, E | |
dc.contributor.author | Munoz-Bellvis, L | |
dc.contributor.author | Balsells, J | |
dc.contributor.author | Costello, E | |
dc.contributor.author | Huang, J | |
dc.contributor.author | Iglesias, M | |
dc.contributor.author | Kleeff, J | |
dc.contributor.author | Kong, B | |
dc.contributor.author | Mora, J | |
dc.contributor.author | Murray, L | |
dc.contributor.author | O'Driscoll, D | |
dc.contributor.author | Poves, I | |
dc.contributor.author | Scarpa, A | |
dc.contributor.author | Ye, W | |
dc.contributor.author | Hidalgo, M | |
dc.contributor.author | Sharp, L | |
dc.contributor.author | Carrato, A | |
dc.contributor.author | Real, FX | |
dc.contributor.author | Malats, N | |
dc.contributor.author | Investigators, PS | |
dc.date.accessioned | 2019-08-13T08:46:44Z | |
dc.date.available | 2018-01-02 | |
dc.date.available | 2019-08-13T08:46:44Z | |
dc.date.issued | 2018-01-10 | |
dc.identifier.citation | E Molina-Montes, P Gomez-Rubio, M Márquez, M Rava, M Löhr, C W Michalski, X Molero, A Farré, J Perea, W Greenhalf, L Ilzarbe, M O’Rorke, A Tardón, T Gress, V M Barberà, T Crnogorac-Jurcevic, E Domínguez-Muñoz, L Muñoz-Bellvís, J Balsells, E Costello, J Huang, M Iglesias, J Kleeff, Bo Kong, J Mora, L Murray, D O’Driscoll, I Poves, A Scarpa, W Ye, M Hidalgo, L Sharp, A Carrato, F X Real, N Malats, the PanGenEU Study Investigators, Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives, International Journal of Epidemiology, Volume 47, Issue 2, April 2018, Pages 473–483, https://doi.org/10.1093/ije/dyx269 | en_US |
dc.identifier.issn | 0300-5771 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/59043 | |
dc.description.abstract | Background
Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk of PC, but little is known regarding the role of inherited/environmental factors or that of FH of other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches.
Methods
Case-control study including 1431 PC cases and 1090 controls and a reconstructed-cohort study (N = 16 747) made up of their first-degree relatives (FDR). Logistic regression was used to evaluate PC risk associated with FH of cancer, diabetes, allergies, asthma, cystic fibrosis and chronic pancreatitis by relative type and number of affected relatives, by smoking status and other potential effect modifiers, and by tumour stage and location. Familial aggregation of cancer was assessed within the cohort using Cox proportional hazard regression.
Results
FH of PC was associated with an increased PC risk [odds ratio (OR) = 2.68; 95% confidence interval (CI): 2.27-4.06] when compared with cancer-free FH, the risk being greater when ≥ 2 FDRs suffered PC (OR = 3.88; 95% CI: 2.96-9.73) and among current smokers (OR = 3.16; 95% CI: 2.56-5.78, interaction FHPC*smoking P-value = 0.04). PC cumulative risk by age 75 was 2.2% among FDRs of cases and 0.7% in those of controls [hazard ratio (HR) = 2.42; 95% CI: 2.16-2.71]. PC risk was significantly associated with FH of cancer (OR = 1.30; 95% CI: 1.13-1.54) and diabetes (OR = 1.24; 95% CI: 1.01-1.52), but not with FH of other diseases.
Conclusions
The concordant findings using both approaches strengthen the notion that FH of cancer, PC or diabetes confers a higher PC risk. Smoking notably increases PC risk associated with FH of PC. Further evaluation of these associations should be undertaken to guide PC prevention strategies. | en_US |
dc.format.extent | 473 - 483 | |
dc.language.iso | en | en_US |
dc.publisher | Oxford University Press | en_US |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | |
dc.rights | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) | |
dc.rights | This is a pre-copyedited, author-produced version of an article accepted for publication in International Journal of Epidemiology following peer review. The version of record E Molina-Montes et al. Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives, International Journal of Epidemiology, Volume 47, Issue 2, April 2018, Pages 473–483 is available online at: https://doi.org/10.1093/ije/dyx269 | |
dc.subject | Pancreatic cancer | en_US |
dc.subject | family cancer | en_US |
dc.subject | epidemiology | en_US |
dc.subject | case-control | en_US |
dc.subject | cohort | en_US |
dc.subject | risk | en_US |
dc.title | Risk of pancreatic cancer associated with family history of cancer and other medical conditions by accounting for smoking among relatives | en_US |
dc.type | Article | en_US |
dc.rights.holder | © The Author(s) 2018; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association | |
dc.identifier.doi | 10.1093/ije/dyx269 | |
pubs.author-url | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430706100023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a | en_US |
pubs.issue | 2 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published | en_US |
pubs.publisher-url | https://doi.org/10.1093/ije/dyx269 | |
pubs.volume | 47 | en_US |
dcterms.dateAccepted | 2018-01-02 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |