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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

dc.contributor.authorKilpeläinen, TO
dc.contributor.authorBentley, AR
dc.contributor.authorNoordam, R
dc.contributor.authorSung, YJ
dc.contributor.authorSchwander, K
dc.contributor.authorWinkler, TW
dc.contributor.authorJakupović, H
dc.contributor.authorChasman, DI
dc.contributor.authorManning, A
dc.contributor.authorNtalla, I
dc.contributor.authorAschard, H
dc.contributor.authorBrown, MR
dc.contributor.authorde Las Fuentes, L
dc.contributor.authorFranceschini, N
dc.contributor.authorGuo, X
dc.contributor.authorVojinovic, D
dc.contributor.authorAslibekyan, S
dc.contributor.authorFeitosa, MF
dc.contributor.authorKho, M
dc.contributor.authorMusani, SK
dc.contributor.authorRichard, M
dc.contributor.authorWang, H
dc.contributor.authorWang, Z
dc.contributor.authorBartz, TM
dc.contributor.authorBielak, LF
dc.contributor.authorCampbell, A
dc.contributor.authorDorajoo, R
dc.contributor.authorFisher, V
dc.contributor.authorHartwig, FP
dc.contributor.authorHorimoto, ARVR
dc.contributor.authorLi, C
dc.contributor.authorLohman, KK
dc.contributor.authorMarten, J
dc.contributor.authorSim, X
dc.contributor.authorSmith, AV
dc.contributor.authorTajuddin, SM
dc.contributor.authorAlver, M
dc.contributor.authorAmini, M
dc.contributor.authorBoissel, M
dc.contributor.authorChai, JF
dc.contributor.authorChen, X
dc.contributor.authorDivers, J
dc.contributor.authorEvangelou, E
dc.contributor.authorGao, C
dc.contributor.authorGraff, M
dc.contributor.authorHarris, SE
dc.contributor.authorHe, M
dc.contributor.authorHsu, F-C
dc.contributor.authorJackson, AU
dc.contributor.authorZhao, JH
dc.contributor.authorKraja, AT
dc.contributor.authorKühnel, B
dc.contributor.authorLaguzzi, F
dc.contributor.authorLyytikäinen, L-P
dc.contributor.authorNolte, IM
dc.contributor.authorRauramaa, R
dc.contributor.authorRiaz, M
dc.contributor.authorRobino, A
dc.contributor.authorRueedi, R
dc.contributor.authorStringham, HM
dc.contributor.authorTakeuchi, F
dc.contributor.authorvan der Most, PJ
dc.contributor.authorVarga, TV
dc.contributor.authorVerweij, N
dc.contributor.authorWare, EB
dc.contributor.authorWen, W
dc.contributor.authorLi, X
dc.contributor.authorYanek, LR
dc.contributor.authorAmin, N
dc.contributor.authorArnett, DK
dc.contributor.authorBoerwinkle, E
dc.contributor.authorBrumat, M
dc.contributor.authorCade, B
dc.contributor.authorCanouil, M
dc.contributor.authorChen, Y-DI
dc.contributor.authorConcas, MP
dc.contributor.authorConnell, J
dc.contributor.authorde Mutsert, R
dc.contributor.authorde Silva, HJ
dc.contributor.authorde Vries, PS
dc.contributor.authorDemirkan, A
dc.contributor.authorDing, J
dc.contributor.authorEaton, CB
dc.contributor.authorFaul, JD
dc.contributor.authorFriedlander, Y
dc.contributor.authorGabriel, KP
dc.contributor.authorGhanbari, M
dc.contributor.authorGiulianini, F
dc.contributor.authorGu, CC
dc.contributor.authorGu, D
dc.contributor.authorHarris, TB
dc.contributor.authorHe, J
dc.contributor.authorHeikkinen, S
dc.contributor.authorHeng, C-K
dc.contributor.authorHunt, SC
dc.contributor.authorIkram, MA
dc.contributor.authorJonas, JB
dc.contributor.authorKoh, W-P
dc.contributor.authorKomulainen, P
dc.contributor.authorKrieger, JE
dc.contributor.authorKritchevsky, SB
dc.contributor.authorKutalik, Z
dc.contributor.authorKuusisto, J
dc.contributor.authorLangefeld, CD
dc.contributor.authorLangenberg, C
dc.contributor.authorLauner, LJ
dc.contributor.authorLeander, K
dc.contributor.authorLemaitre, RN
dc.contributor.authorLewis, CE
dc.contributor.authorLiang, J
dc.contributor.authorLifelines Cohort Study
dc.contributor.authorLiu, J
dc.contributor.authorMägi, R
dc.contributor.authorManichaikul, A
dc.contributor.authorMeitinger, T
dc.contributor.authorMetspalu, A
dc.contributor.authorMilaneschi, Y
dc.contributor.authorMohlke, KL
dc.contributor.authorMosley, TH
dc.contributor.authorMurray, AD
dc.contributor.authorNalls, MA
dc.contributor.authorNang, E-EK
dc.contributor.authorNelson, CP
dc.contributor.authorNona, S
dc.contributor.authorNorris, JM
dc.contributor.authorNwuba, CV
dc.contributor.authorO'Connell, J
dc.contributor.authorPalmer, ND
dc.contributor.authorPapanicolau, GJ
dc.contributor.authorPazoki, R
dc.contributor.authorPedersen, NL
dc.contributor.authorPeters, A
dc.contributor.authorPeyser, PA
dc.contributor.authorPolasek, O
dc.contributor.authorPorteous, DJ
dc.contributor.authorPoveda, A
dc.contributor.authorRaitakari, OT
dc.contributor.authorRich, SS
dc.contributor.authorRisch, N
dc.contributor.authorRobinson, JG
dc.contributor.authorRose, LM
dc.contributor.authorRudan, I
dc.contributor.authorSchreiner, PJ
dc.contributor.authorScott, RA
dc.contributor.authorSidney, SS
dc.contributor.authorSims, M
dc.contributor.authorSmith, JA
dc.contributor.authorSnieder, H
dc.contributor.authorSofer, T
dc.contributor.authorStarr, JM
dc.contributor.authorSternfeld, B
dc.contributor.authorStrauch, K
dc.contributor.authorTang, H
dc.contributor.authorTaylor, KD
dc.contributor.authorTsai, MY
dc.contributor.authorTuomilehto, J
dc.contributor.authorUitterlinden, AG
dc.contributor.authorvan der Ende, MY
dc.contributor.authorvan Heemst, D
dc.contributor.authorVoortman, T
dc.contributor.authorWaldenberger, M
dc.contributor.authorWennberg, P
dc.contributor.authorWilson, G
dc.contributor.authorXiang, Y-B
dc.contributor.authorYao, J
dc.contributor.authorYu, C
dc.contributor.authorYuan, J-M
dc.contributor.authorZhao, W
dc.contributor.authorZonderman, AB
dc.contributor.authorBecker, DM
dc.contributor.authorBoehnke, M
dc.contributor.authorBowden, DW
dc.contributor.authorde Faire, U
dc.contributor.authorDeary, IJ
dc.contributor.authorElliott, P
dc.contributor.authorEsko, T
dc.contributor.authorFreedman, BI
dc.contributor.authorFroguel, P
dc.contributor.authorGasparini, P
dc.contributor.authorGieger, C
dc.contributor.authorKato, N
dc.contributor.authorLaakso, M
dc.contributor.authorLakka, TA
dc.contributor.authorLehtimäki, T
dc.contributor.authorMagnusson, PKE
dc.contributor.authorOldehinkel, AJ
dc.contributor.authorPenninx, BWJH
dc.contributor.authorSamani, NJ
dc.contributor.authorShu, X-O
dc.contributor.authorvan der Harst, P
dc.contributor.authorVan Vliet-Ostaptchouk, JV
dc.contributor.authorVollenweider, P
dc.contributor.authorWagenknecht, LE
dc.contributor.authorWang, YX
dc.contributor.authorWareham, NJ
dc.contributor.authorWeir, DR
dc.contributor.authorWu, T
dc.contributor.authorZheng, W
dc.contributor.authorZhu, X
dc.contributor.authorEvans, MK
dc.contributor.authorFranks, PW
dc.contributor.authorGudnason, V
dc.contributor.authorHayward, C
dc.contributor.authorHorta, BL
dc.contributor.authorKelly, TN
dc.contributor.authorLiu, Y
dc.contributor.authorNorth, KE
dc.contributor.authorPereira, AC
dc.contributor.authorRidker, PM
dc.contributor.authorTai, ES
dc.contributor.authorvan Dam, RM
dc.contributor.authorFox, ER
dc.contributor.authorKardia, SLR
dc.contributor.authorLiu, C-T
dc.contributor.authorMook-Kanamori, DO
dc.contributor.authorProvince, MA
dc.contributor.authorRedline, S
dc.contributor.authorvan Duijn, CM
dc.contributor.authorRotter, JI
dc.contributor.authorKooperberg, CB
dc.contributor.authorGauderman, WJ
dc.contributor.authorPsaty, BM
dc.contributor.authorRice, K
dc.contributor.authorMunroe, PB
dc.contributor.authorFornage, M
dc.contributor.authorCupples, LA
dc.contributor.authorRotimi, CN
dc.contributor.authorMorrison, AC
dc.contributor.authorRao, DC
dc.contributor.authorLoos, RJF
dc.date.accessioned2019-08-06T14:02:16Z
dc.date.available2018-12-07
dc.date.available2019-08-06T14:02:16Z
dc.date.issued2019-01-22
dc.identifier.issn2041-1723
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/58847
dc.description.abstractMany genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.en_US
dc.format.extent376
dc.languageeng
dc.language.isoenen_US
dc.publisherNature Research (part of Springer Nature)en_US
dc.relation.ispartofNat Commun
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
dc.titleMulti-ancestry study of blood lipid levels identifies four loci interacting with physical activity.en_US
dc.typeArticleen_US
dc.rights.holder© The Author(s) 2019
dc.identifier.doi10.1038/s41467-018-08008-w
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30670697en_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.publication-statusPublished onlineen_US
pubs.publisher-urlhttps://doi.org/10.1038/s41467-018-08008-w
pubs.volume10en_US
dcterms.dateAccepted2018-12-07
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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