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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

dc.contributor.authorBentley, AR
dc.contributor.authorSung, YJ
dc.contributor.authorBrown, MR
dc.contributor.authorWinkler, TW
dc.contributor.authorKraja, AT
dc.contributor.authorNtalla, I
dc.contributor.authorSchwander, K
dc.contributor.authorChasman, DI
dc.contributor.authorLim, E
dc.contributor.authorDeng, X
dc.contributor.authorGuo, X
dc.contributor.authorLiu, J
dc.contributor.authorLu, Y
dc.contributor.authorCheng, C-Y
dc.contributor.authorSim, X
dc.contributor.authorVojinovic, D
dc.contributor.authorHuffman, JE
dc.contributor.authorMusani, SK
dc.contributor.authorLi, C
dc.contributor.authorFeitosa, MF
dc.contributor.authorRichard, MA
dc.contributor.authorNoordam, R
dc.contributor.authorBaker, J
dc.contributor.authorChen, G
dc.contributor.authorAschard, H
dc.contributor.authorBartz, TM
dc.contributor.authorDing, J
dc.contributor.authorDorajoo, R
dc.contributor.authorManning, AK
dc.contributor.authorRankinen, T
dc.contributor.authorSmith, AV
dc.contributor.authorTajuddin, SM
dc.contributor.authorZhao, W
dc.contributor.authorGraff, M
dc.contributor.authorAlver, M
dc.contributor.authorBoissel, M
dc.contributor.authorChai, JF
dc.contributor.authorChen, X
dc.contributor.authorDivers, J
dc.contributor.authorEvangelou, E
dc.contributor.authorGao, C
dc.contributor.authorGoel, A
dc.contributor.authorHagemeijer, Y
dc.contributor.authorHarris, SE
dc.contributor.authorHartwig, FP
dc.contributor.authorHe, M
dc.contributor.authorHorimoto, ARVR
dc.contributor.authorHsu, F-C
dc.contributor.authorHung, Y-J
dc.contributor.authorJackson, AU
dc.contributor.authorKasturiratne, A
dc.contributor.authorKomulainen, P
dc.contributor.authorKuehnel, B
dc.contributor.authorLeander, K
dc.contributor.authorLin, K-H
dc.contributor.authorLuan, J
dc.contributor.authorLyytikainen, L-P
dc.contributor.authorMatoba, N
dc.contributor.authorNolte, IM
dc.contributor.authorPietzner, M
dc.contributor.authorPrins, B
dc.contributor.authorRiaz, M
dc.contributor.authorRobino, A
dc.contributor.authorSaid, MA
dc.contributor.authorSchupf, N
dc.contributor.authorScott, RA
dc.contributor.authorSofer, T
dc.contributor.authorStancakova, A
dc.contributor.authorTakeuchi, F
dc.contributor.authorTayo, BO
dc.contributor.authorvan der Most, PJ
dc.contributor.authorVarga, TV
dc.contributor.authorWang, T-D
dc.contributor.authorWang, Y
dc.contributor.authorWare, EB
dc.contributor.authorWen, W
dc.contributor.authorXiang, Y-B
dc.contributor.authorYanek, LR
dc.contributor.authorZhang, W
dc.contributor.authorZhao, JH
dc.contributor.authorAdeyemo, A
dc.contributor.authorAfaq, S
dc.contributor.authorAmin, N
dc.contributor.authorAmini, M
dc.contributor.authorArking, DE
dc.contributor.authorArzumanyan, Z
dc.contributor.authorAung, T
dc.contributor.authorBallantyne, C
dc.contributor.authorBarr, RG
dc.contributor.authorBielak, LF
dc.contributor.authorBoerwinkle, E
dc.contributor.authorBottinger, EP
dc.contributor.authorBroeckel, U
dc.contributor.authorBrown, M
dc.contributor.authorCade, BE
dc.contributor.authorCampbell, A
dc.contributor.authorCanouil, M
dc.contributor.authorCharumathi, S
dc.contributor.authorChen, Y-DI
dc.contributor.authorChristensen, K
dc.contributor.authorConcas, MP
dc.contributor.authorConnell, JM
dc.contributor.authorde las Fuentes, L
dc.contributor.authorde Silva, HJ
dc.contributor.authorde Vries, PS
dc.contributor.authorDoumatey, A
dc.contributor.authorDuan, Q
dc.contributor.authorEaton, CB
dc.contributor.authorEppinga, RN
dc.contributor.authorFaul, JD
dc.contributor.authorFloyd, JS
dc.contributor.authorForouhi, NG
dc.contributor.authorForrester, T
dc.contributor.authorFriedlander, Y
dc.contributor.authorGandin, I
dc.contributor.authorGao, H
dc.contributor.authorGhanbari, M
dc.contributor.authorGharib, SA
dc.contributor.authorGigante, B
dc.contributor.authorGiulianini, F
dc.contributor.authorGrabe, HJ
dc.contributor.authorGu, CC
dc.contributor.authorHarris, TB
dc.contributor.authorHeikkinen, S
dc.contributor.authorHeng, C-K
dc.contributor.authorHirata, M
dc.contributor.authorHixson, JE
dc.contributor.authorIkram, MA
dc.contributor.authorJia, Y
dc.contributor.authorJoehanes, R
dc.contributor.authorJohnson, C
dc.contributor.authorJonas, JB
dc.contributor.authorJustice, AE
dc.contributor.authorKatsuya, T
dc.contributor.authorKhor, CC
dc.contributor.authorKilpelainen, TO
dc.contributor.authorKoh, W-P
dc.contributor.authorKolcic, I
dc.contributor.authorKooperberg, C
dc.contributor.authorKrieger, JE
dc.contributor.authorKritchevsky, SB
dc.contributor.authorKubo, M
dc.contributor.authorKuusisto, J
dc.contributor.authorLakka, TA
dc.contributor.authorLangefeld, CD
dc.contributor.authorLangenberg, C
dc.contributor.authorLauner, LJ
dc.contributor.authorLehne, B
dc.contributor.authorLewis, CE
dc.contributor.authorLi, Y
dc.contributor.authorLiang, J
dc.contributor.authorLin, S
dc.contributor.authorLiu, C-T
dc.contributor.authorLiu, J
dc.contributor.authorLiu, K
dc.contributor.authorLoh, M
dc.contributor.authorLohman, KK
dc.contributor.authorLouie, T
dc.contributor.authorLuzzi, A
dc.contributor.authorMagi, R
dc.contributor.authorMahajan, A
dc.contributor.authorManichaikul, AW
dc.contributor.authorMcKenzie, CA
dc.contributor.authorMeitinger, T
dc.contributor.authorMetspalu, A
dc.contributor.authorMilaneschi, Y
dc.contributor.authorMilani, L
dc.contributor.authorMohlke, KL
dc.contributor.authorMomozawa, Y
dc.contributor.authorMorris, AP
dc.contributor.authorMurray, AD
dc.contributor.authorNalls, MA
dc.contributor.authorNauck, M
dc.contributor.authorNelson, CP
dc.contributor.authorNorth, KE
dc.contributor.authorO'Connell, JR
dc.contributor.authorPalmer, ND
dc.contributor.authorPapanicolau, GJ
dc.contributor.authorPedersen, NL
dc.contributor.authorPeters, A
dc.contributor.authorPeyser, PA
dc.contributor.authorPolasek, O
dc.contributor.authorPoulter, N
dc.contributor.authorRaitakari, OT
dc.contributor.authorReiner, AP
dc.contributor.authorRenstrom, F
dc.contributor.authorRice, TK
dc.contributor.authorRich, SS
dc.contributor.authorRobinson, JG
dc.contributor.authorRose, LM
dc.contributor.authorRosendaal, FR
dc.contributor.authorRudan, I
dc.contributor.authorSchmidt, CO
dc.contributor.authorSchreiner, PJ
dc.contributor.authorScott, WR
dc.contributor.authorSever, P
dc.contributor.authorShi, Y
dc.contributor.authorSidney, S
dc.contributor.authorSims, M
dc.contributor.authorSmith, JA
dc.contributor.authorSnieder, H
dc.contributor.authorStarr, JM
dc.contributor.authorStrauch, K
dc.contributor.authorStringham, HM
dc.contributor.authorTan, NYQ
dc.contributor.authorTang, H
dc.contributor.authorTaylor, KD
dc.contributor.authorTeo, YY
dc.contributor.authorTham, YC
dc.contributor.authorTiemeier, H
dc.contributor.authorTurner, ST
dc.contributor.authorUitterlinden, AG
dc.contributor.authorvan Heemst, D
dc.contributor.authorWaldenberger, M
dc.contributor.authorWang, H
dc.contributor.authorWang, L
dc.contributor.authorWang, L
dc.contributor.authorWei, WB
dc.contributor.authorWilliams, CA
dc.contributor.authorSr, WG
dc.contributor.authorWojczynski, MK
dc.contributor.authorYao, J
dc.contributor.authorYoung, K
dc.contributor.authorYu, C
dc.contributor.authorYuan, J-M
dc.contributor.authorZhou, J
dc.contributor.authorZonderman, AB
dc.contributor.authorBecker, DM
dc.contributor.authorBoehnke, M
dc.contributor.authorBowden, DW
dc.contributor.authorChambers, JC
dc.contributor.authorCooper, RS
dc.contributor.authorde Faire, U
dc.contributor.authorDeary, IJ
dc.contributor.authorElliott, P
dc.contributor.authorEsko, T
dc.contributor.authorFarrall, M
dc.contributor.authorFranks, PW
dc.contributor.authorFreedman, BI
dc.contributor.authorFroguel, P
dc.contributor.authorGasparini, P
dc.contributor.authorGieger, C
dc.contributor.authorHorta, BL
dc.contributor.authorJuang, J-MJ
dc.contributor.authorKamatani, Y
dc.contributor.authorKammerer, CM
dc.contributor.authorKato, N
dc.contributor.authorKooner, JS
dc.contributor.authorLaakso, M
dc.contributor.authorLaurie, CC
dc.contributor.authorLee, I-T
dc.contributor.authorLehtimaki, T
dc.contributor.authorMagnusson, PKE
dc.contributor.authorOldehinkel, AJ
dc.contributor.authorPenninx, BWJH
dc.contributor.authorPereira, AC
dc.contributor.authorRauramaa, R
dc.contributor.authorRedline, S
dc.contributor.authorSamani, NJ
dc.contributor.authorScott, J
dc.contributor.authorShu, X-O
dc.contributor.authorvan der Harst, P
dc.contributor.authorWagenknecht, LE
dc.contributor.authorWang, J-S
dc.contributor.authorWang, YX
dc.contributor.authorWareham, NJ
dc.contributor.authorWatkins, H
dc.contributor.authorWeir, DR
dc.contributor.authorWickremasinghe, AR
dc.contributor.authorWu, T
dc.contributor.authorZeggini, E
dc.contributor.authorZheng, W
dc.contributor.authorBouchard, C
dc.contributor.authorEvans, MK
dc.contributor.authorGudnason, V
dc.contributor.authorKardia, SLR
dc.contributor.authorLiu, Y
dc.contributor.authorPsaty, BM
dc.contributor.authorRidker, PM
dc.contributor.authorvan Dam, RM
dc.contributor.authorMook-Kanamori, DO
dc.contributor.authorFornage, M
dc.contributor.authorProvince, MA
dc.contributor.authorKelly, TN
dc.contributor.authorFox, ER
dc.contributor.authorHayward, C
dc.contributor.authorvan Duijn, CM
dc.contributor.authorTai, ES
dc.contributor.authorWong, TY
dc.contributor.authorLoos, RJF
dc.contributor.authorFranceschini, N
dc.contributor.authorRotter, JI
dc.contributor.authorZhu, X
dc.contributor.authorBierut, LJ
dc.contributor.authorGauderman, WJ
dc.contributor.authorRice, K
dc.contributor.authorMunroe, PB
dc.contributor.authorMorrison, AC
dc.contributor.authorRao, DC
dc.contributor.authorRotimi, CN
dc.contributor.authorCupples, LA
dc.contributor.authorConsortium, C-K
dc.contributor.authorConsortium, E-I
dc.contributor.authorGrp, USS
dc.contributor.authorCohort, L
dc.date.accessioned2019-08-06T11:20:41Z
dc.date.available2019-02-07
dc.date.available2019-08-06T11:20:41Z
dc.date.issued2019-03-29
dc.identifier.issn1061-4036
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/58835
dc.description.abstractThe concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.en_US
dc.format.extent636 - 648
dc.language.isoenen_US
dc.publisherNature Research (part of Springer Nature)en_US
dc.relation.ispartofNATURE GENETICS
dc.titleMulti-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipidsen_US
dc.typeArticleen_US
dc.rights.holderCopyright © 2019, Springer Nature
dc.identifier.doi10.1038/s41588-019-0378-y
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000462767500011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.publisher-urlhttps://doi.org/10.1038/s41588-019-0378-y
pubs.volume51en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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