RESULTS OF INTENSIVE ALGORITHM-BASED SCREENING IN THE UK FAMILIAL OVARIAN CANCER SCREENING STUDY (UK FOCSS PHASE 2)
Volume
23
Publisher
DOI
10.1097/01.IGC.0000437414.49882.6a
Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Issue
ISSN
1048-891X
Metadata
Show full item recordAbstract
Objectives
To establish the performance of intensive screening for familial ovarian cancer
using the risk of ovarian cancer algorithm (ROCA) and transvaginal sonogrpahy
(TVS).
Methods
Between 14/06/2007 and 29/03/2012, 4,531 women at an estimated ≥10% lifetime
risk of OC/FTC were screened by 42 UK centres for 14,263 women screen years
with 4-monthly CA125 analysed by the ROCA. TVS was annual but brought
forward if ROCA results were non-normal. Women with suspicious scan and/or
algorithm results were referred for possible surgical intervention. Participants were
followed prospectively by centres, questionnaire and cancer registries. Data was
censored 365 days after final screen, withdrawal or death.