RESULTS OF INTENSIVE ALGORITHM-BASED SCREENING IN THE UK FAMILIAL OVARIAN CANCER SCREENING STUDY (UK FOCSS PHASE 2)
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
MetadataShow full item record
Objectives To establish the performance of intensive screening for familial ovarian cancer using the risk of ovarian cancer algorithm (ROCA) and transvaginal sonogrpahy (TVS). Methods Between 14/06/2007 and 29/03/2012, 4,531 women at an estimated ≥10% lifetime risk of OC/FTC were screened by 42 UK centres for 14,263 women screen years with 4-monthly CA125 analysed by the ROCA. TVS was annual but brought forward if ROCA results were non-normal. Women with suspicious scan and/or algorithm results were referred for possible surgical intervention. Participants were followed prospectively by centres, questionnaire and cancer registries. Data was censored 365 days after final screen, withdrawal or death.