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dc.contributor.authorFeber, A
dc.contributor.authorWorth, DC
dc.contributor.authorChakravarthy, A
dc.contributor.authorde Winter, P
dc.contributor.authorShah, K
dc.contributor.authorArya, M
dc.contributor.authorSaqib, M
dc.contributor.authorNigam, R
dc.contributor.authorMalone, PR
dc.contributor.authorTan, WS
dc.contributor.authorRodney, S
dc.contributor.authorFreeman, A
dc.contributor.authorJameson, C
dc.contributor.authorWilson, GA
dc.contributor.authorPowles, T
dc.contributor.authorBeck, S
dc.contributor.authorFenton, T
dc.contributor.authorSharp, TV
dc.contributor.authorMuneer, A
dc.contributor.authorKelly, JD
dc.date.accessioned2019-03-21T10:24:57Z
dc.date.available2016-05-09
dc.date.available2019-03-21T10:24:57Z
dc.date.issued2016-06-20
dc.identifier.issn0008-5472
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/56388
dc.description.abstractOther than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to determine the somatic mutational landscape of penile cancer. WES was performed on penile cancer and matched germline DNA from 27 patients undergoing surgical resection. Targeted resequencing of candidate genes was performed in an independent 70 patient cohort. Mutation data were also integrated with DNA methylation and copy-number information from the same patients. We identified an HPV-associated APOBEC mutation signature and an NpCpG signature in HPV-negative disease. We also identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1. Expression of CSN1 mutants in cells resulted in colocalization with AGO2 in cytoplasmic P-bodies, ultimately leading to the loss of miRNAmediated gene silencing, which may contribute to disease etiology. Our findings represent the first comprehensive analysis of somatic alterations in penile cancer, highlighting the complex landscape of alterations in this malignancy.en_US
dc.description.sponsorshipOrchid (The Male Cancer Charity).en_US
dc.format.extent4720 - 4727
dc.language.isoenen_US
dc.publisherAmerican Association for Cancer Researchen_US
dc.relation.ispartofCANCER RESEARCH
dc.titleCSN1 Somatic Mutations in Penile Squamous Cell Carcinomaen_US
dc.typeArticleen_US
dc.rights.holder©2016 American Association for Cancer Research.
dc.identifier.doi10.1158/0008-5472.CAN-15-3134
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000382297700014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue16en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.volume76en_US
dcterms.dateAccepted2016-05-09
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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