Browsing Queen Mary University of London Theses by Subject "pancreatic ductal adenocarcinoma"
Now showing items 1-3 of 3
-
Aberrant downstream mechanisms following depletion of KMT2C and KMT2D in Pancreatic Ductal Adenocarcinoma
(Queen Mary University of London, 2017-03-20)Genomic sequencing of pancreatic ductal adenocarcinoma (PDAC) tumours has highlighted the existence of wide genetic diversity alongside frequent mutations in KRAS, TP53 and SMAD4. Within this heterogeneity many components ... -
Output-based mesh adaptation using geometric multi-grid for error estimation
(Queen Mary University of London, 12/08/2019)The adjoint method in computational fluid dynamics (CFD) made shape optimisation affordable. However, the typical cost of the process is still at least an order of magnitude higher than obtaining a ow solution only. In ... -
Role of Polymeric Immunoglobulin Receptor in pancreatic ductal adenocarcinoma
(Queen Mary University of London, 2017-11-26)Introduction: Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work has demonstrated pIgR ...