Browsing Queen Mary University of London Theses by Subject "macrophages"
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Reimagining Criminal Justice Through the Lens of The African Union
(Queen Mary University of London, 11/02/2019)In 2014 the African Union (AU) and African states set in motion the establishment of African justice mechanisms for addressing international crimes including a new section of the African Court of Justice and Human and ... -
Relationship between altered myoepithelial phenotype and the inflammatory cell infiltrate in progression of DCIS
(Queen Mary University of London, 2015-08-01)Changes in the microenvironment have been implicated in the transition of pre-invasive ductal carcinoma in-situ (DCIS) to invasive breast cancer. Normal myoepithelial cells have a tumour suppressor phenotype but they are ... -
The role of P13K p1168 in the regulation of gene expression in murine macrophages.
(Queen Mary University of London, 2012)PI3K are a family of lipid kinase enzymes that are involved in a broad spectrum of cellular, physiological and pathological processes. Notably, PI3K dysfunction is associated with cancer, inflammation and metabolism. The ... -
The role of the tumour microenvironment in arginine deprivation in malignant pleural mesothelioma
(Queen Mary University of London, 2016-10-07)Approximately 50% of all malignant pleural mesotheliomas (MPM) are deficient in argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine biosynthesis, and are sensitive to arginine deprivation. This discovery ... -
THE ROLE OF TUMOUR-ASSOCIATED MACROPHAGES IN PANCREATIC CANCER
(Queen Mary University of London, 2017-12-21)Pancreatic ductal adenocarcinoma is a highly desmoplastic tumour, and non-malignant stromal cells contribute to progression and treatment resistance. Inflammatory cells in particular are known drivers of carcinogenesis, ...