Browsing Queen Mary University of London Theses by Subject "Mutation"
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Development and description of a novel inducible model of salivary gland inflammation in C57BL/6 mice characterised by tertiary lymphoid structures, autoimmunity and exocrine dysfunction
(Queen Mary University of London, 06/02/2015)The accumulation of leukocytes in non-lymphoid tissues and their structural organization into tertiary lymphoid structures (TLS), a process known as ectopic lymphoid neogenesis (ELN), is observed in response to chronic ... -
Dissection of drug resistance mechanisms in FGFR2 mutant endometrial cancer.
(Queen Mary University of London, 2015-01)Mutations in FGFR2 are common in a subset of endometrial carcinomas. Given the emergence of small molecule inhibitors specific to this receptor tyrosine kinase, FGFR2 is an attractive therapeutic target. However, compensatory ...