Browsing Queen Mary University of London Theses by Title
Now showing items 1559-1578 of 4150
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Generalisation with sparse evidence: the role of predispositions and experience
(2022)Generalisation is an important part of learning in many species. It enables learners to build new knowledge from previous experience and allows them to adapt to novel situations (Banich & Caccamise, 2011; Dehaene, 2020). ... -
Generalized Conditional Entropies and Applications to Channel Ordering and Design
(2023)Generalized conditional entropies (GCEs) are a fundamental concept in the field of Quantitative Information Flow (QIF), the field concerned with quantifying information leakage in security systems. Different entropies ... -
Generating Molecularly-Controlled Biomaterials Using Host-Guest Guided Peptide Amphiphile Self-Assembly
(Queen Mary University of London, 2020-04-28)Supramolecular chemistry offers a unique opportunity to assemble biomaterials with molecular precision. Though biomaterials based on self-assembling peptides often exhibit limited control over their hierarchical assembly, ... -
Generating Uniformly-Distributed Random Generalised 2-designs with Block Size 3
(Queen Mary University of London, 2012-12)Generalised t-designs, defined by Cameron, describe a generalisation of many combinatorial objects including: Latin squares, 1-factorisations of K2n (the complete graph on 2n vertices), and classical t-designs. This new ... -
The generation of α4β7+CLA+ T cells and their role in Inflammatory Bowel Disease
This study describes a novel population of T cells that co-express gut homing integrin α4β7 and skin trafficking glycoprotein CLA, termed ‘dual tropic’ T cells. This population is unique as expression of gut and skin homing ... -
A Generic Software Library for Creating Multimedia Browse/Search Applications
(Queen Mary University of London, 1996)This thesis surveys the field of browse/search interactions. The results of this study form the basis of a specification of a representation scheme and a library of access functions which facilitate the creation of ... -
Genes and type 2 diabetes: polymorphisms of the EIF2AK3 gene and its relationship to type 2 diabetes mellitus
(Queen Mary University of London, 2010)Aims/ Hypothesis: Wolcott- Rallison syndrome (WRS) is a rare autosomal recessively inherited Mendelian disorder. It is characterised by a short trunk compared to arm span, multiple epiphyseal dysplasia, multiple fractures, ... -
Genetic analysis of candidate genes linked to atopic eczema in the Bangladeshi population of East London
(Queen Mary University of London, 2010)Background: Atopic Eczema (AE) is a common skin disease that results from a complex interplay between genetic and environmental factors. It may be associated with other atopic phenotypes including; asthma, hayfever and ... -
Genetic and functional basis of connexins in disease
(Queen Mary University of London, 2011)Gap junctions are composed of connexin (Cx) proteins and permit the transfer of small molecules between cells. Six Cx proteins assemble to form a hemichannel, which can dock with an adjacent hemichannel on another cell to ... -
The genetic and functional basis of three inherited cutaneous and gastrointestinal diseases in humans
(Queen Mary University of London, 29/05/2014)This thesis describes investigations into the genetic basis and pathophysiology of three distinct inherited diseases in humans, two of which are strongly associated to the function of the ectodomain sheddase enzyme ADAM17. The ... -
The Genetic and Functional Basis of Three Inherited Palmoplantar Keratodermas in Human Disease.
(Queen Mary University of London., 2020-09-03)The ability of cells to respond to stress is fundamental for survival. The palmoplantar epidermis, by its very nature, is subjected to substantial external forces. At birth, the skin at these sites is similar to the skin ... -
The Genetic and Functional Role of ABCA12 in Harlequin Ichthyosis
(Queen Mary University of London, 2016-02-19)Harlequin Ichthyosis (HI) is the most severe disorder in the family of autosomal recessive congenital ichthyosis (ARCI). Recessive mutations in the ABC transporter ABCA12 were found to be causative in HI. Loss of ABCA12 ... -
Genetic and Functional Studies Provide Insights into the Aetiologies of Familial Combined Hyperlipidemia
(Queen Mary University of London, 2012-01)The integration of biological and genetic data has established that diverse biological processes, involving multiple effectors, influence circulating levels of triglyceride and cholesterol. This diversity may underlie ... -
GENETIC AND PHENOTYPIC CHARACTERISATION OF CHILDREN WITH GROWTH HORMONE INSENSITIVITY OR IGF-1 INSENSITIVITY
(2023)Patients with defects in the growth hormone (GH) – insulin-like growth factor 1 (IGF-1) axis leading to growth hormone insensitivity (GHI) or IGF-1 insensitivity frequently present with severe short stature phenotypes ... -
Genetic determinants of vitamin D status and susceptibility to acute respiratory infection
(Queen Mary University of London, 2016-02-29)Acute respiratory infections (ARI) are a major global cause of morbidity and mortality. Vitamin D deficiency has been reported to associate with susceptibility to ARI and with greater severity and poorer control of asthma ... -
The Genetic Landscape of Mnemon Aggregation in Budding Yeast
(2022)In budding yeast, the G1/S inhibitor Whi3 has been identified to encode and maintain cellular memory during mating. In response to deceptive courtship, budding yeast escapes pheromone-induced cell cycle arrest through the ... -
Genetic regulation of the host response to cardiac surgery and cardiopulmonary bypass
(Queen Mary University of London, 2017-12-15)There is significant variation between individual patients in the magnitude and pattern of their systemic response to cardiac surgery. Poor outcomes in these patients have been associated with a dysfunctional host response. ... -
Genetic risk variants in intestinal inflammatory disorders
(Queen Mary University of London, 2010)This thesis includes work on the genetics of intestinal inflammatory disorders, concentrating on coeliac disease and Crohn’s disease. It explores how common genetic variants influence risk of complex phenotypes including ... -
The Genetic Status of the PIK3CA Oncogene and Activity of the PI3K-AKTmTOR Pathway in Penile Squamous Cell Carcinoma
(Queen Mary University of London, 2017-03-15)Penile squamous cell carcinoma (PSCC) is rare; hence little is known about its aetiology and pathogenesis. Two challenges exist in the clinical management of PSCC patients. Firstly, finding a non-invasive method to aid the ... -
GENETIC SUSCEPTIBILITY TO TYPE II DIABETES AND OBESITY: THE ROLE OF UCP2, UCP3 AND CAPN10 GENES
(Queen Mary University of London, 2002)The global prevalence of type 2 diabetes (T2DM) and obesity is increasing, with obesity the most important predisposing factor contributing to the development of T2DM. Epidemiological and genetic evidence supports a major ...