Browsing Queen Mary University of London Theses by Title
Now showing items 1499-1518 of 4128
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Functional characterisation of relaxin-type neuropeptide signalling in an echinoderm
(2023)Relaxin-type peptides were first identified in mammals as regulators of reproductive processes. Discovery of relaxin-type peptide in Drosophila and starfish has revealed that these are evolutionarily ancient peptides. ... -
Functional Characterisation of the Genes Mutated in Dyskeratosis Congenita.
(Queen Mary University of London, 2013-02)Dyskeratosis congenita (DC) is a multi system disorder that exhibits considerable clinical and genetic heterogeneity. It is characterised by mucocutaneous features, bone marrow failure and a predisposition to cancer. ... -
Functional characterisation of VAV-interacting Krüppel-like factor (VIK) in breast cancer
(Queen Mary University of London, 2017-01-20)Background. VAV interacting Krüppel-like factor (VIK) is a novel transcription factor. Previously our lab reported a series of breast cancer tumour samples where VIK methylation was associated with an increased risk of ... -
Functional characterization of solute carrier family 39 member 8 variant in relation to hypertension and coronary artery disease.
(Queen Mary University of London, 2015-12-03)Hypertension and coronary artery disease are complex diseases with both environmental and genetic contributions. Genome-wide association studies (GWASs) have revealed a number of common genetic variants with modest effects ... -
Functional Composite Inorganic Nanoparticles/Polyelectrolyte Microcapsules: Synthesis and Properties
Functionalization of drug carriers using engineered inorganic nanoparticles (NPs) is currently an important topic. Polyelectrolyte microcapsules, as one of potential drug delivery systems, can be facilely functionalized ... -
Functional Data Analysis in Orthogonal Designs with Applications to Gait Patterns
(Queen Mary University of London, 2018-08-23)This thesis presents a contribution to the active research area of functional data analysis (FDA) and is concerned with the analysis of data from complex experimental designs in which the responses are curves. High ... -
Functional effects of anti-neuronal antibodies in patients with encephalitis lethargica and related disorders associated with streptococcal infection
(Queen Mary University of London, 2014)Encephalitis lethargica affected a large number of people in the pandemic in the early 1900s (von Economo, 1930). Histological and biochemical data suggest that autoimmune mechanisms play an important role in this disorder ... -
Functional Films and Fibres based on Liquid Crystal Coatings
(Queen Mary University of London, 30/01/2015)This thesis aims to produce functional polymer fibres and films using liquid crystal networks or photoembossing. The work focuses on visual effects in fibres, optical sensing properties and, actuation and morphing properties. ... -
Functional Gastrointestinal Disorders and the Joint Hypermobility Syndrome
(Queen Mary University of London, 2013)Despite the fact that functional gastrointestinal disorders (FGID), such as irritable bowel syndrome, are common, our understanding of them is limited. The Joint Hypermobility Syndrome (JHS) is a common non-inflammator ... -
Functional impact of microRNA-34a on stem cell differentiation towards smooth muscle cell
(Queen Mary University of London, 2014)MicroRNAs play an important role in biological regulation. Recently miR-34a has been reported to regulate tumour cell cycle progression and apoptosis. However, the functional role of miR-34a in smooth muscle cell (SMC) ... -
FUNCTIONAL LIVER TESTS IN LIVER DISEASE
(2023-12-18)The liver is subject to several insults, whether from ingested chemicals, pathogens or genetic diseases. Many of these are transient and full function returns. However, chronic injury may lead to scarring, the volume and ... -
The functional mechanism of electron transfer within photosynthetic complex I in cyanobacteria
(Queen Mary University of London, 2021-12)Photosynthesis relies upon a proton motive force to produce ATP. Photosynthetic complex I (PS-CI) is a member of the complex I family involved in cyclic electron flow and respiration in cyanobacteria. PS-CI couples ferredoxin ... -
Functional Polymers via Cu-mediated Radical Polymerization
(Queen Mary University of London, 2018-03-21)This work reports the investigation of Cu-mediated polymerization systems and its limits, in order to obtain functional branched polymers, in particular star-shaped and graft-shaped polymers. A novel initiator structure ... -
Functional role of the PD-1:PD-L1 pathway in T-cell:Endothelial cell interactions
Programmed death-1 (PD-1) receptor and its ligand PD-L1 are key components of the T-cell co-inhibitory pathway. PD-1 is expressed by activated T-cells, while PD-L1 is expressed on both T-cells and antigen presenting cells. ... -
Functional Roles of microRNA-214 in Modulating Smooth Muscle Cell Functions and Neointima Formation
(Queen Mary University of London, 11/01/2019)Vascular Smooth Muscle cells (VSMCs) have very important role in pathogenesis of atherosclerosis and neointima formation. VSMCs phenotype switching and resultant increase in migration and proliferation under the influence ... -
Functional Studies of Genetic Variants in TRPM7 and AKAP9 – Two Candidate Genes for Stillbirth
(Queen Mary University of London, 08/11/2018)For every 200 births in the UK, one will end in a stillbirth. Stillbirth is classified as a baby born dead after 24 weeks gestation. Mutations in genes that cause ion channelopathies are known to cause sudden cardiac death ... -
A functional study of ADAMTS7 gene variants.
(Queen Mary University of London, 2014-03)Background: Recent studies have revealed an association between genetic variants at the ADAMTS7 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 7) locus and susceptibility to coronary artery ... -
A functional study of blood-pressure-associated SNPs at natriuretic peptide receptor C gene locus.
(Queen Mary University of London, 2016-05-12)Background: Essential hypertension is regarded as a complex disease, the phenotype of which results from interactions between numerous genes and environmental factors. Genome-wide association studies of blood pressure (BP) ... -
Functional Topology of Networks
(Queen Mary University of London, 2016-08-15)In order to utilise network resources efficiently, we need a strong knowledge of how the resources are shared and provisioned. However,this information is often unavailable due to the complexity of modern networks, the ... -
THE FUNCTIONS OF ARBITRAL INSTITUTIONS: THEORETICAL REPRESENTATIONS AND PRACTICAL REALITIES
(Queen Mary University of London, 18/12/2014)While thousands of cross-border disputes are resolved each year through institutional arbitration, there appears to be little understanding of the role of arbitral institutions. In particular, very little academic scholarship ...