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The potential therapeutic role of selenium in diffuse large B-cell lymphoma
(2011)
The clinical background to this work confirms the very poor outcome of patients with recurrent diffuse large B-cell lymphoma (DLBCL) and highlights the need for better therapies. One such potential option would be to add ...
Prostate cancer targeting using replication-selective adenoviruses in combination with phytochemicals
(2009)
Oncolytic adenoviral mutants have demonstrated good safety profiles but, despite some
encouraging clinical results, efficacy as a single agent was limited. Combinations with
conventional chemo- or radiotherapy significantly ...
DNA methylation in follicular lymphoma
(2010)
Follicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced ...
Pharmacokinetic studies of drug absorption into human skin
(2010)
Optimum therapeutic outcomes require not only proper drug selection but also effective
drug delivery and monitoring. The aim of this thesis was to A) study drug delivery
through the skin with a liquid formulated to ...
The correlation of keratin expression with in-vitro epithelial cell line differentiation
(2009)
The mechanism of transcriptional regulation which allows oral mucosal-specific
expression of the human keratin 13 (K13) gene remains unknown. The pattern of
expression of keratin genes in the oral mucosa shows sequential ...
Systematic analysis of genomic alterations in prostate cancer
(2011)
Prostate cancer is the most common male cancer in Western countries. The genetic
mechanism underlying its initiation and progression is still unclear. The aim of this
project was to identify novel genomic changes in ...
Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment
(2010)
Approximately one-third of the global population is infected with tuberculosis causing
approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect
against TB, but it cannot prevent primary infection ...
The relationship of human chorionic gonadotropin beta (hCGβ) expression and luteinizing hormone gene mutation (vLH) with prostate cancer in population groups of multi-ethnic origin
(2007)
Data have shown that Black men have the highest incidence and mortality from prostate cancer in the world. Even after adjusting for stage at diagnosis, black men have higher mortality rates than white men (Freedland, 2005). ...
Identification of adenovirus E1A gene regions involved in chemosensitisation of prostate cancer cells
(2009)
Replication-selective adenoviruses are promising anti-cancer therapies
(virotherapy). Viruses can be engineered to selectively target cancer cells by
deleting viral genes involved in cell cycle regulation. These deletions ...
Rapid Access Chest Pain Clinics: characteristics and outcomes of patients from six centres
(2009)
Background Despite the widespread proliferation of rapid access chest pain clinics (RACPCs), there remain outstanding questions about their effectiveness. The aim of my thesis is to determine:
Aim 1) the variation in the ...
