Browsing Centre for Oral Immunobiology and Regenerative Medicine by Issue Date
Now showing items 1-20 of 406
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Genetic regulation of mouse glycosylphosphatidylinositol-phospholipase D
(Elsevier, 2004-04-23)Glycosylphosphatidylinositol phospholipase D (GPI-PLD) has been proposed to be responsible for cleaving membrane-associated glycosylphosphatidyl inositol (GPI) molecules to generate inositol phosphoglycan (IPGs), which ... -
Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed.
(2004-05-12)BACKGROUND: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors. The anti-anthrax toxin human monoclonal ... -
Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor.
(2004-07-29)BACKGROUND: The circumsporozoite surface protein is the primary target of human antibodies against Plasmodium falciparum sporozoites, these antibodies are predominantly directed to the major repetitive epitope (Asn-Pro-Asn-Ala)n, ... -
Cognate peptide-receptor ligand mapping by directed phage display.
(2005-06-17)BACKGROUND: A rapid phage display method for the elucidation of cognate peptide specific ligand for receptors is described. The approach may be readily integrated into the interface of genomic and proteomic studies to ... -
Lipid rafts in T cell signalling and disease
(2007-10) -
Tuberculous orbital apex syndromes.
(2008-11)AIMS: To describe the clinical and radiological features of orbital apex syndromes caused by presumed tuberculosis (TB). METHODS: A review of the discharge summaries of all patients seen in the Medical Eye Unit (MEU), St ... -
Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
(National Academy of Sciences, 2008-12-09)The ultimate goal for the treatment of autoimmunity is to restore immunological tolerance. Regulatory T cells (Treg) play a central role in immune tolerance, and Treg functional abnormalities have been identified in different ... -
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
(2010)Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been ... -
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
(Wiley Online, 2010-01-26)CTLA‐4 is a critical gatekeeper of T‐cell activation and immunological tolerance and has been implicated in patients with a variety of autoimmune diseases through genetic association. Since T cells from patients with the ...