Browsing Centre for Oral Immunobiology and Regenerative Medicine by Issue Date
Now showing items 21-40 of 531
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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
(2010)Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been ... -
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
(Wiley Online, 2010-01-26)CTLA‐4 is a critical gatekeeper of T‐cell activation and immunological tolerance and has been implicated in patients with a variety of autoimmune diseases through genetic association. Since T cells from patients with the ... -
Protein Phosphorylation and Kinome Profiling Reveal Altered Regulation of Multiple Signaling Pathways in B Lymphocytes From Patients With Systemic Lupus Erythematosus
(Wiley Online, 2010-08-03)Objective The cause of B lymphocyte hyperactivity and autoantibody production in systemic lupus erythematosus (SLE) remains unclear. Previously, we identified abnormalities in the level and translocation of signaling ... -
Paratransgenic Control of Vector Borne Diseases
(Ivyspring International Publisher., 2011-11-01)Conventional methodologies to control vector borne diseases with chemical pesticides are often associated with environmental toxicity, adverse effects on human health and the emergence of insect resistance. In the ... -
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
(2012)The oncogene FOXM1 has been implicated in all major types of human cancer. We recently showed that aberrant FOXM1 expression causes stem cell compartment expansion resulting in the initiation of hyperplasia. We have ... -
Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling
(2012)Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles. However, in certain clinical situations ... -
FOXM1 coming of age: time for translation into clinical benefits?
(2012)A decade since the first evidence implicating the cell cycle transcription factor Forkhead Box M1 (FOXM1) in human tumorigenesis, a slew of subsequent studies revealed an oncogenic role of FOXM1 in the majority of human ... -
Endogenous endophthalmitis and liver abscesses.
(2012)We present a case of endogenous endophthalmitis secondary to liver abscesses, in a patient with no previous medical comorbidities or risk factors for immunosuppression. The patient presented with acute painless loss of ...
