dc.contributor.author | Escala-Garcia, M | |
dc.contributor.author | Guo, Q | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Canisius, S | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Beesley, J | |
dc.contributor.author | Lecarpentier, J | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Abraham, J | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Auer, PL | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Behrens, S | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Bermisheva, M | |
dc.contributor.author | Bernstein, L | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Boeckx, B | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Bonanni, B | |
dc.contributor.author | Børresen-Dale, A-L | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Brentnall, A | |
dc.contributor.author | Brinton, L | |
dc.contributor.author | Broberg, P | |
dc.contributor.author | Brock, IW | |
dc.contributor.author | Brucker, SY | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Caldas, C | |
dc.contributor.author | Caldés, T | |
dc.contributor.author | Campa, D | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Carracedo, A | |
dc.contributor.author | Carter, BD | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Cheng, T-YD | |
dc.contributor.author | Chin, S-F | |
dc.contributor.author | Clarke, CL | |
dc.contributor.author | NBCS Collaborators | |
dc.contributor.author | Cordina-Duverger, E | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, DG | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Dunn, JA | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Durcan, L | |
dc.contributor.author | Dwek, M | |
dc.contributor.author | Earl, HM | |
dc.contributor.author | Ekici, AB | |
dc.contributor.author | Eliassen, AH | |
dc.contributor.author | Ellberg, C | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Eriksson, M | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Flesch-Janys, D | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Gabrielson, M | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Galle, E | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | García-Sáenz, JA | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | George, A | |
dc.contributor.author | Georgoulias, V | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | Alnæs, GIG | |
dc.contributor.author | Grip, M | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Haeberle, L | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Hankinson, S | |
dc.contributor.author | Harkness, EF | |
dc.contributor.author | Harrington, PA | |
dc.contributor.author | Hart, SN | |
dc.contributor.author | Hartikainen, JM | |
dc.contributor.author | Hein, A | |
dc.contributor.author | Hillemanns, P | |
dc.contributor.author | Hiller, L | |
dc.contributor.author | Holleczek, B | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hoover, RN | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Howell, A | |
dc.contributor.author | Huang, G | |
dc.contributor.author | Humphreys, K | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Janni, W | |
dc.contributor.author | John, EM | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Jukkola-Vuorinen, A | |
dc.contributor.author | Jung, A | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Kabisch, M | |
dc.contributor.author | Kaczmarek, K | |
dc.contributor.author | Kerin, MJ | |
dc.contributor.author | Khan, S | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Kiiski, JI | |
dc.contributor.author | Kitahara, CM | |
dc.contributor.author | Knight, JA | |
dc.contributor.author | Ko, Y-D | |
dc.contributor.author | Koppert, LB | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Krüger, U | |
dc.contributor.author | Kühl, T | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Lee, E | |
dc.contributor.author | Lejbkowicz, F | |
dc.contributor.author | Li, L | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Lindström, S | |
dc.contributor.author | Linet, M | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Lo, W-Y | |
dc.contributor.author | Loibl, S | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Lux, MP | |
dc.contributor.author | MacInnis, RJ | |
dc.contributor.author | Maierthaler, M | |
dc.contributor.author | Maishman, T | |
dc.contributor.author | Makalic, E | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Manoochehri, M | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Martinez, ME | |
dc.contributor.author | Mavroudis, D | |
dc.contributor.author | McLean, C | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Middha, P | |
dc.contributor.author | Miller, N | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Moreno, F | |
dc.contributor.author | Mulligan, AM | |
dc.contributor.author | Mulot, C | |
dc.contributor.author | Nassir, R | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Newman, WT | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Norman, A | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Pankratz, VS | |
dc.contributor.author | Park-Simon, T-W | |
dc.contributor.author | Perez, JIA | |
dc.contributor.author | Pérez-Barrios, C | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Petridis, C | |
dc.contributor.author | Pinchev, M | |
dc.contributor.author | Prajzendanc, K | |
dc.contributor.author | Prentice, R | |
dc.contributor.author | Presneau, N | |
dc.contributor.author | Prokofieva, D | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Rack, B | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Ramachandran, D | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Rennert, HS | |
dc.contributor.author | Rhenius, V | |
dc.contributor.author | Romero, A | |
dc.contributor.author | Roylance, R | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmidt, DF | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Schneeweiss, A | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Schumacher, F | |
dc.contributor.author | Schwentner, L | |
dc.contributor.author | Scott, RJ | |
dc.contributor.author | Scott, C | |
dc.contributor.author | Seynaeve, C | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Smeets, A | |
dc.contributor.author | Sohn, C | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Talhouk, A | |
dc.contributor.author | Tamimi, RM | |
dc.contributor.author | Tapper, WJ | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Tengström, M | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Thöne, K | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Turman, C | |
dc.contributor.author | Turnbull, C | |
dc.contributor.author | Ulmer, H-U | |
dc.contributor.author | Untch, M | |
dc.contributor.author | Vachon, C | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | van den Ouweland, AMW | |
dc.contributor.author | van Veen, EM | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Whittemore, AS | |
dc.contributor.author | Willett, W | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Yang, XR | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Schmidt, MK | |
dc.date.accessioned | 2019-03-13T15:54:59Z | |
dc.date.available | 2019-01-14 | |
dc.date.available | 2019-03-13T15:54:59Z | |
dc.date.issued | 2019-02-21 | |
dc.identifier.citation | Escala-Garcia, M., et al. (2019). "Genome-wide association study of germline variants and breast cancer-specific mortality." British Journal of Cancer. | en_US |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/56178 | |
dc.description.abstract | BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10-7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10-7, HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients. | en_US |
dc.description.sponsorship | BCAC is funded by Cancer Research UK [C1287/A16563 and C1287/A10118], the European Union’s Horizon 2020 Research and Innovation Programme (Grant numbers 634935 and 633784 for BRIDGES and B-CAST, respectively), and by the European Community's Seventh Framework Programme under grant agreement number 223175 (Grant number HEALTH-F2-2009-223175) (COGS). | en_US |
dc.language | eng | |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.ispartof | Br J Cancer | |
dc.rights | Creative Commons Attribution | |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Genome-wide association study | en_US |
dc.subject | breast cancer | en_US |
dc.subject | Mortality | en_US |
dc.title | Genome-wide association study of germline variants and breast cancer-specific mortality. | en_US |
dc.type | Article | en_US |
dc.rights.holder | The Author(s) 2019 | |
dc.identifier.doi | 10.1038/s41416-019-0393-x | |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30787463 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
dcterms.dateAccepted | 2019-01-14 | |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |