Centre for Genomics and Child Health: Recent submissions
Now showing items 1-20 of 835
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Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome.
(Frontiers Media, 2022-10-05)The potential health consequences of glyphosate-induced gut microbiome alterations have become a matter of intense debate. As part of a multifaceted study investigating toxicity, carcinogenicity and multigenerational effects ... -
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease.
(Wiley, 2024-04-29)Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages ... -
Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease.
(Lippincott, Williams & Wilkins, 2024-01-29)Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently available analgesics often lack efficacy or have intolerable side effects, ... -
Areca catechu-(Betel-nut)-induced whole transcriptome changes in a human monocyte cell line that may have relevance to diabetes and obesity; a pilot study.
(2021-08-14)BACKGROUND: Betel-nut consumption is the fourth most common addictive habit globally and there is good evidence linking the habit to obesity, type 2 diabetes (T2D) and the metabolic syndrome. The aim of our pilot study was ... -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.
(Wiley, 2024-02-07)Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic ... -
MDB-16. TARGETING EPIGENETIC DYSREGULATION IN PAEDIATRIC BRAIN TUMOURS
(Oxford University Press (OUP), 2023-06-12) -
DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts.
(2024-06-06)BACKGROUND: DNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially correlated across the genome, typically high in repressed regions but low ... -
Ribosomal DNA copy number variation associates with hematological profiles and renal function in the UK Biobank.
(2024-05-10)The phenotypic impact of genetic variation of repetitive features in the human genome is currently understudied. One such feature is the multi-copy 47S ribosomal DNA (rDNA) that codes for rRNA components of the ribosome. ... -
Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants
(Nature Research, 2024-04-17)Children who are HIV-exposed but uninfected have increased infectious mortality compared to HIV-unexposed children, raising the possibility of immune abnormalities following exposure to maternal viraemia, immune dysfunction, ... -
Locomotion system for a medical device
(Patent Application Publication, 2024-01-25)A locomotion system for use in a medical device, including at least one magnet, a rotor including a plurality of coil windings, and a ferromagnetic member. The rotor is configured, on application of a current to the plurality ... -
Evaluation of clinical examination and preoperative imaging in patients with right iliac fossa pain and a medium or high risk score for appendicitis (RIFT-2)
(Impact Health, 2024-04-12)Introduction: Clinical risk models can be used to safely stratify UK patients with suspected appendicitis with low scores to ambulatory pathways, preventing admissions and unnecessary surgery. This study aimed to examine ... -
Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in patients living with or beyond cancer: SUrvivors' Rehabilitation Evaluation after CANcer (SURECAN) trial.
(2024-04-02)BACKGROUND: Two million people in the UK are living with or beyond cancer and a third of them report poor quality of life (QoL) due to problems such as fatigue, fear of cancer recurrence, and concerns about returning to ... -
Efficacy of oral corticosteroids for acute preschool wheeze: a systematic review and individual participant data meta-analysis of randomised clinical trials.
(2024-03-22)BACKGROUND: Oral corticosteroids are commonly used for acute preschool wheeze, although there is conflicting evidence of their benefit. We assessed the clinical efficacy of oral corticosteroids by means of a systematic ... -
Outdoor air pollution and near-fatal/fatal asthma attacks in children: A systematic review.
(2024-03-13)BACKGROUND: Globally, observational studies have demonstrated an association between high levels of air pollution and asthma attacks in children. It remains unclear whether and to what extent exposure may be associated ... -
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
(Nature Research, 2024-02-19)Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution ... -
Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition.
(2024-02-28)Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge ...