Browsing Centre for Genomics and Child Health by Subject "Mammals"
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DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts.
(2024-06-06)BACKGROUND: DNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially correlated across the genome, typically high in repressed regions but low ... -
LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions.
(BioMed Central, 2021-02-18)BACKGROUND: To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals. ...