Browsing Centre for Genomics and Child Health by Subject "Gene Expression Profiling"
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Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
(2009)BACKGROUND: Although paediatric high grade gliomas resemble their adult counterparts in many ways, there appear to be distinct clinical and biological differences. One important factor hampering the development of new ... -
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease.
(Wiley, 2024-04-29)Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages ... -
Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease.
(Lippincott, Williams & Wilkins, 2024-01-29)Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently available analgesics often lack efficacy or have intolerable side effects, ...