Browsing Centre for Genomics and Child Health by Subject "Administration, Oral"

Now showing items 1-3 of 3

    • Causes of impaired oral vaccine efficacy in developing countries. 

      Parker, EP; Ramani, S; Lopman, BA; Church, JA; Iturriza-Gómara, M; Prendergast, AJ; Grassly, NC (2018-01)
      Oral vaccines are less immunogenic when given to infants in low-income compared with high-income countries, limiting their potential public health impact. Here, we review factors that might contribute to this phenomenon, ...

    • Exploring the relationship between environmental enteric dysfunction and oral vaccine responses. 

      Church, JA; Parker, EP; Kosek, MN; Kang, G; Grassly, NC; Kelly, P; Prendergast, AJ (2018-07)
      Oral vaccines significantly underperform in low-income countries. One possible contributory factor is environmental enteric dysfunction (EED), a subclinical disorder of small intestinal structure and function among children ...

    • Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants. 

      Church, JA; Rukobo, S; Govha, M; Carmolli, MP; Diehl, SA; Chasekwa, B; Ntozini, R; Mutasa, K; Humphrey, JH; Kirkpatrick, BD (2017-11-02)
      It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe ...