Browsing Centre for Genomics and Child Health by Author "Yuan, W"
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The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation
Bell, CG; Yuan, W; Gao, F; Xia, Y; Bourne, E; Wozniak, E; Bell, J; Lillycrop, K; Wang, J; Dennison, EThe epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ~46kb (<0.002% genome), is the second most abundant cellular transcript. tRNAs also control ...