Browsing Centre for Genomics and Child Health by Author "Yang, WR"
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Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.
Cheng, KCL; Frost, JM; Sánchez-Luque, FJ; García-Canãdas, M; Taylor, D; Yang, WR; Irayanar, B; Sampath, S; Patani, H; Agger, K (2023-10-16)BACKGROUND: Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling ...