Browsing Centre for Genomics and Child Health by Author "Wu, Y"
Now showing items 1-4 of 4
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Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy
Fertan, E; Böken, D; Murray, A; Danial, JSH; Lam, JYL; Wu, Y; Goh, PA; Alić, I; Cheetham, MR; Lobanova, E (Springer Nature, 2023-12-15)Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in Alzheimer's disease (AD) is of great importance for the rational design of preventative therapies. Here we report a set of methods for the ... -
Genetic mechanisms of critical illness in Covid-19.
Pairo-Castineira, E; Clohisey, S; Klaric, L; Bretherick, AD; Rawlik, K; Pasko, D; Walker, S; Parkinson, N; Fourman, MH; Russell, CD (2020-12-11)Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 ... -
A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population
Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; Gou, X; Wang, G; Sun, Z; Xu, J; Xu, H (2016-04-19) -
Mapping the human genetic architecture of COVID-19
Niemi, MEK; Karjalainen, J; Daly, M; Ganna, A; Mehtonen, J; Cordioli, M; Kaunisto, M; Pigazzini, S; Donner, K; Kivinen, K (2021)