Browsing Centre for Genomics and Child Health by Author "Wozniak, E"
Now showing items 1-4 of 4
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The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation
Bell, CG; Yuan, W; Gao, F; Xia, Y; Bourne, E; Wozniak, E; Bell, J; Lillycrop, K; Wang, J; Dennison, EThe epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ~46kb (<0.002% genome), is the second most abundant cellular transcript. tRNAs also control ... -
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
Hunt, KA; Mistry, V; Bockett, NA; Ahmad, T; Ban, M; Barker, JN; Barrett, JC; Blackburn, H; Brand, O; Burren, O (2013) -
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease.
Humphreys, DT; Lewis, A; Pan-Castillo, B; Berti, G; Mein, C; Wozniak, E; Gordon, H; Gadhok, R; Minicozzi, A; ChinAleong, J (Wiley, 2024-04-29)Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages ... -
Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease.
Higham, JP; Bhebhe, CN; Gupta, RA; Tranter, MM; Barakat, FM; Dogra, H; Bab, N; Wozniak, E; Barker, KH; Wilson, CH (Lippincott, Williams & Wilkins, 2024-01-29)Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently available analgesics often lack efficacy or have intolerable side effects, ...