Browsing Centre for Genomics and Child Health by Author "Szubert, AJ"
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Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy
Prendergast, AJ; Szubert, AJ; Berejena, C; Pimundu, G; Pala, P; Shonhai, A; Musiime, V; Bwakura-Dangarembizi, M; Poulsom, H; Hunter, P (Oxford University Press, 2016-05-18)Background. Identifying determinants of morbidity and mortality may help target future interventions for human immunodeficiency virus (HIV)–infected children. Methods. CD4+ T-cell count, HIV viral load, and levels of ... -
Causes and Timing of Mortality and Morbidity Among Late Presenters Starting Antiretroviral Therapy in the REALITY Trial.
Post, FA; Szubert, AJ; Prendergast, AJ; Johnston, V; Lyall, H; Fitzgerald, F; Musiime, V; Musoro, G; Chepkorir, P; Agutu, C (Oxford University Press (OUP), 2018-03-04)Background: In sub-Saharan Africa, 20%-25% of people starting antiretroviral therapy (ART) have severe immunosuppression; approximately 10% die within 3 months. In the Reduction of EArly mortaLITY (REALITY) randomized ... -
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
Bourke, CD; Gough, EK; Pimundu, G; Shonhai, A; Berejena, C; Terry, L; Baumard, L; Choudhry, N; Karmali, Y; Bwakura-Dangarembizi, M (2019-04-03) -
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.
Mallewa, J; Szubert, AJ; Mugyenyi, P; Chidziva, E; Thomason, MJ; Chepkorir, P; Abongomera, G; Baleeta, K; Etyang, A; Warambwa, C (Elsevier/Science Direct, 2018-04-10)BACKGROUND: In sub-Saharan Africa, severely immunocompromised HIV-infected individuals have a high risk of mortality during the first few months after starting antiretroviral therapy (ART). We hypothesise that universally ... -
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
Hakim, J; Musiime, V; Szubert, AJ; Siika, A; Mallewa, J; Agutu, C; Pett, SL; Bwakura-Dangarembizi, M; Lugemwa, A; Kaunda, S (Wiley on behalf of International AIDS Society, 2016-07-22)Meeting abstract FRAB0101LB from 21st International AIDS Conference 18–22 July 2016, Durban, South Africa. Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among ... -
Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa
Hakim, J; Musiime, V; Szubert, AJ; Mallewa, J; Siika, A; Agutu, C; Walker, S; Pett, SL; Bwakura-Dangarembizi, M; Lugemwa, A (2017-07-20) -
Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe
Prendergast, AJ; Berejena, C; Pimundu, G; Shonhai, A; Bwakura-Dangarembizi, M; Musiime, V; Szubert, AJ; Cook, AD; Spyer, MJ; Nahirya-Ntege, P (2019-07-15) -
Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial.
Szubert, AJ; Prendergast, AJ; Spyer, MJ; Musiime, V; Musoke, P; Bwakura-Dangarembizi, M; Nahirya-Ntege, P; Thomason, MJ; Ndashimye, E; Nkanya, I (2017-11)BACKGROUND: Although WHO recommends viral load (VL) monitoring for those on antiretroviral therapy (ART), availability in low-income countries remains limited. We investigated long-term VL and resistance in HIV-infected ...