Browsing Centre for Genomics and Child Health by Author "Kvartsberg, H"
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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
Alic, I; Goh, PA; Murray, A; Portelius, E; Gkanatsiou, E; Gough, G; Mok, KY; Koschut, D; Brunmeir, R; Yeap, YJ (Nature Research, 2020-07-10)A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an ... -
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain (Jul, 10.1038/S41380-020-0806-5, 2020)
Alic, I; Goh, PA; Murray, A; Portelius, E; Gkanatsiou, E; Gough, G; Mok, KY; Koschut, D; Brunmeir, R; Yeap, YJ (2021)