Browsing Centre for Genomics and Child Health by Author "Jacobs, BM"
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Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.
Williams, AT; Chen, J; Coley, K; Batini, C; Izquierdo, A; Packer, R; Abner, E; Kanoni, S; Shepherd, DJ; Free, RC (2023-10-23)Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide ... -
Influence of autozygosity on common disease risk across the phenotypic spectrum.
Malawsky, DS; van Walree, E; Jacobs, BM; Heng, TH; Huang, QQ; Sabir, AH; Rahman, S; Sharif, SM; Khan, A; Mirkov, MU (2023-09-20)Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in ...