Browsing Centre for Genomics and Child Health by Author "Gutierrez-Achury, J"
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Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
Gutierrez-Achury, J; Zhernakova, A; Pulit, SL; Trynka, G; Hunt, KA; Romanos, J; Raychaudhuri, S; Van Heel, DA; Wijmenga, C; De Bakker, PIW (2015-05-27)© 2015 Nature America, Inc. All rights reserved. Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine ... -
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
Gutierrez-Achury, J; Zhernakova, A; Pulit, SL; Trynka, G; Hunt, KA; Romanos, J; Raychaudhuri, S; van Heel, DA; Wijmenga, C; de Balcker, PIW (2015-06) -
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
Marquez, A; Kerick, M; Zhernakova, A; Gutierrez-Achury, J; Chen, W-M; Onengut-Gumuscu, S; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Rios-Fernandez, R; Gonzalez-Gay, MA (2018) -
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
Lenz, TL; Deutsch, AJ; Han, B; Hu, X; Okada, Y; Eyre, S; Knapp, M; Zhernakova, A; Huizinga, TWJ; Abecasis, G (2015-08-27)© 2015 Nature America, Inc. All rights reserved. Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen-binding ...