Browsing Centre for Genomics and Child Health by Author "Erskine, L"
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CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1
Appleby, LJ; Nausch, N; Erskine, L; Bourke, CD; Rujeni, N; Midzi, N; Mduluza, T; Mutapi, F (Public Library of Science, 2014-08-07)Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total ... -
Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.
Appleby, LJ; Nausch, N; Heard, F; Erskine, L; Bourke, CD; Midzi, N; Mduluza, T; Allen, JE; Mutapi, F (Frontiers, 2015)The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions. Down regulation ...