Browsing Centre for Genomics and Child Health by Author "D'Souza, H"
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Aligning cognitive studies in mouse models and human infants/toddlers: The case of Down Syndrome
D'Souza, H; Brady, D; Wiseman, FK; Good, MA; Thomas, MSC; Strydom, A; Fisher, E; Nizetic, D; Hardy, J; Tybulewicz, V (2021-05-17) -
Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray, A; Gough, G; Cindrić, A; Vučković, F; Koschut, D; Borelli, V; Petrović, DJ; Bekavac, A; Plećaš, A; Hribljan, V (2023-08)BACKGROUND: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, ...