Browsing Centre for Genomics and Child Health by Author "Bwakura-Dangarembizi, M"
Now showing items 1-15 of 15
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Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy
Prendergast, AJ; Szubert, AJ; Berejena, C; Pimundu, G; Pala, P; Shonhai, A; Musiime, V; Bwakura-Dangarembizi, M; Poulsom, H; Hunter, P (Oxford University Press, 2016-05-18)Background. Identifying determinants of morbidity and mortality may help target future interventions for human immunodeficiency virus (HIV)–infected children. Methods. CD4+ T-cell count, HIV viral load, and levels of ... -
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
Bourke, CD; Gough, EK; Pimundu, G; Shonhai, A; Berejena, C; Terry, L; Baumard, L; Choudhry, N; Karmali, Y; Bwakura-Dangarembizi, M (2019-04-03) -
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.
Mallewa, J; Szubert, AJ; Mugyenyi, P; Chidziva, E; Thomason, MJ; Chepkorir, P; Abongomera, G; Baleeta, K; Etyang, A; Warambwa, C (Elsevier/Science Direct, 2018-04-10)BACKGROUND: In sub-Saharan Africa, severely immunocompromised HIV-infected individuals have a high risk of mortality during the first few months after starting antiretroviral therapy (ART). We hypothesise that universally ... -
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
Hakim, J; Musiime, V; Szubert, AJ; Siika, A; Mallewa, J; Agutu, C; Pett, SL; Bwakura-Dangarembizi, M; Lugemwa, A; Kaunda, S (Wiley on behalf of International AIDS Society, 2016-07-22)Meeting abstract FRAB0101LB from 21st International AIDS Conference 18–22 July 2016, Durban, South Africa. Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among ... -
Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa
Hakim, J; Musiime, V; Szubert, AJ; Mallewa, J; Siika, A; Agutu, C; Walker, S; Pett, SL; Bwakura-Dangarembizi, M; Lugemwa, A (2017-07-20) -
Fat and lean mass predict time to hospital readmission or mortality in children treated for complicated severe acute malnutrition in Zimbabwe and Zambia
Bwakura-Dangarembizi, M; Dumbura, C; Ngosa, DD; Majo, FD; Piper, JP; Sturgeon, JJ; Nathoo, K; Amadi, B; Norris, S; Chasekwa, B (2022) -
Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition.
Sturgeon, JP; Tome, J; Dumbura, C; Majo, FD; Ngosa, D; Mutasa, K; Zyambo, K; Besa, E; Chandwe, K; Kapoma, C (2024-02-28)Severe acute malnutrition (SAM) is the most high-risk form of undernutrition, particularly when children require hospitalization for complications. Complicated SAM is a multisystem disease with high inpatient and postdischarge ... -
Inflammation: the driver of poor outcomes among children with severe acute malnutrition?
Sturgeon, JP; Njunge, JM; Bourke, CD; Gonzales, GB; Robertson, RC; Bwakura-Dangarembizi, M; Berkley, JA; Kelly, P; Prendergast, AJ (2023) -
Inflammatory biomarkers in HIV-infected children hospitalized for severe malnutrition in Uganda and Zimbabwe
Prendergast, AJ; Berejena, C; Pimundu, G; Shonhai, A; Bwakura-Dangarembizi, M; Musiime, V; Szubert, AJ; Cook, AD; Spyer, MJ; Nahirya-Ntege, P (2019-07-15) -
Late Presentation With HIV in Africa: Phenotypes, Risk, and Risk Stratification in the REALITY Trial.
Siika, A; McCabe, L; Bwakura-Dangarembizi, M; Kityo, C; Mallewa, J; Berkley, J; Maitland, K; Griffiths, A; Baleeta, K; Mudzingwa, S (Oxford University Press, 2018-03-04)Background: Severely immunocompromised human immunodeficiency virus (HIV)-infected individuals have high mortality shortly after starting antiretroviral therapy (ART). We investigated predictors of early mortality and "late ... -
Recovery of children following hospitalisation for complicated severe acute malnutrition
Bwakura-Dangarembizi, M; Dumbura, C; Amadi, B; Chasekwa, B; Ngosa, D; Majo, FD; Sturgeon, JP; Chandwe, K; Kapoma, C; Bourke, CD (2022) -
Reduced bacterial skin infections in HIV-infected African children randomized to long-term cotrimoxazole prophylaxis
Prendergast, AJ; Bwakura-Dangarembizi, M; Mugyenyi, P; Lutaakome, J; Kekitiinwa, A; Thomason, MJ; Gibb, DM; Walker, AS; Team, ARROWT (Wolters Kluwer Health, Inc, 2016-11-28)Objective: To evaluate whether cotrimoxazole prophylaxis prevents common skin conditions in HIV-infected children. Design: Open-label randomized controlled trial of continuing versus stopping daily cotrimoxazole ... -
Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.
Phiri, TN; Mutasa, K; Rukobo, S; Govha, M; Mushayanembwa, P; Mwakamui, S; Haider, T; Zyambo, K; Dumbura, C; Tome, J (2023-11-03)Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) ... -
Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe
Gough, EK; Bourke, CD; Berejena, C; Shonhai, A; Bwakura-Dangarembizi, M; Prendergast, AJ; Manges, AR (2020) -
Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial.
Szubert, AJ; Prendergast, AJ; Spyer, MJ; Musiime, V; Musoke, P; Bwakura-Dangarembizi, M; Nahirya-Ntege, P; Thomason, MJ; Ndashimye, E; Nkanya, I (2017-11)BACKGROUND: Although WHO recommends viral load (VL) monitoring for those on antiretroviral therapy (ART), availability in low-income countries remains limited. We investigated long-term VL and resistance in HIV-infected ...