Browsing Centre for Genomics and Child Health by Author "23andMe Research Team"
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Influence of autozygosity on common disease risk across the phenotypic spectrum.
Malawsky, DS; van Walree, E; Jacobs, BM; Heng, TH; Huang, QQ; Sabir, AH; Rahman, S; Sharif, SM; Khan, A; Mirkov, MU (2023-09-20)Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in ... -
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Meng, X; Navoly, G; Giannakopoulou, O; Levey, DF; Koller, D; Pathak, GA; Koen, N; Lin, K; Adams, MJ; Rentería, ME (2024-02)Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and ...