Browsing Centre for Genomics and Child Health by Title
Now showing items 714-733 of 835
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Safely Enhancing Surgical Ward Patient Flow in the Bed Shortage Era by a Modified “Safer red2green” Multi-Disciplinary Board Round. A Quality Improvement Research Report.
(Preprint, 2021-09-03)BackgroundAcute hospital bed shortage is a serious concern worldwide, constantly involving high-dependency units (HDU), where the non-availability of postoperative beds results in surgery cancellation. In the acute medicine ... -
Schistosoma haematobium Treatment in 1–5 Year Old Children: Safety and Efficacy of the Antihelminthic Drug Praziquantel
(Public Library of Science, 2011-05-17)Background Morbidity due to schistosomiasis is currently controlled by treatment of schistosome infected people with the antihelminthic drug praziquantel (PZQ). Children aged up to 5 years are currently excluded from ... -
Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels
(Public Library of Science, 2011-05-06)In animal experimental models, parasitic helminth infections can protect the host from auto-immune diseases. We conducted a population-scale human study investigating the relationship between helminth parasitism and ... -
Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products
(Wiley Online, 2013-02-12)Infection of the human host by schistosome parasites follows exposure of skin to free‐swimming cercariae and is aided by the release of excretory/secretory (E/S) material, which is rich in proteases and glycoconjugates. ... -
Schistosomiasis in the first 1000 days
(2018-06) -
School-based self-management interventions for asthma in children and adolescents: a mixed methods systematic review.
(Wiley, 2019-01-28)BACKGROUND: Asthma is a common respiratory condition in children that is characterised by symptoms including wheeze, shortness of breath, chest tightness, and cough. Children with asthma may be able to manage their condition ... -
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans.
(2017-12-19)Background: DUOX2 and DUOXA2 form the predominant H2O2-producing system in human colorectal mucosa. Inflammation, hypoxia, and 5-aminosalicylic acid increase H2O2 production, supporting innate defense and mucosal healing. ... -
SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells.
(2018-01-19)BACKGROUND: Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ... -
Severe acute malnutrition promotes bacterial binding over proinflammatory cytokine secretion by circulating innate immune cells.
(2023-11-03)Children with severe acute malnutrition (SAM) have high infectious mortality and morbidity, implicating defects in their immune defenses. We hypothesized that circulating innate immune cells from children (0 to 59 months) ... -
Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency
(Elsevier, 2013)