Browsing Centre for Genomics and Child Health by Title
Now showing items 596-615 of 835
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Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
(2017-01)BACKGROUND: Neurodevelopment is strongly influenced by maternal and early-postnatal diet. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are vital structural and functional components of the developing brain. The gut ... -
One- and two-year visual outcomes from the Moorfields age-related macular degeneration database: a retrospective cohort study and an open science resource.
(2019-06-21)OBJECTIVES: To analyse treatment outcomes and share clinical data from a large, single-centre, well-curated database (8174 eyes/6664 patients with 120 756 single entries) of patients with neovascular age-related macular ... -
Optimal age and outcome measures for Alzheimer's disease prevention trials in people with Down syndrome
(Wiley Open Access, 2020-11-23)INTRODUCTION: People with Down syndrome (DS) typically develop Alzheimer's disease (AD) neuropathology before age 40, but a lack of outcome measures and longitudinal data have impeded their inclusion in randomized controlled ... -
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections.
(American Association for the Advancement of Science, 2021-09-10)Duchenne muscular dystrophy (DMD) is caused by dystrophin gene mutations leading to skeletal muscle weakness and wasting. Dystrophin is enriched at the neuromuscular junction (NMJ), but how NMJ abnormalities contribute to ... -
OS07.6.A INVESTIGATING REGIONAL HETEROGENEITY AND PROGRESSION-ASSOCIATED MARKERS IN OLIGODENDROGLIOMAS
(Oxford University Press (OUP), 2023-09-08) -
Outdoor air pollution and near-fatal/fatal asthma attacks in children: A systematic review.
(2024-03-13)BACKGROUND: Globally, observational studies have demonstrated an association between high levels of air pollution and asthma attacks in children. It remains unclear whether and to what extent exposure may be associated ... -
Oxidative stress, short-term exposure to air pollution, and lung function in children
(European Respiratory Society, 2017-12-06)Background: Although the mechanism underlying air pollution exposure’s adverse effects on lung function is unclear, oxidative stress is implicated in a range of adverse health effects of air pollution. Urinary 8-Oxo-2'-d ... -
P03.08.A HIGH-DIMENSIONAL CHARACTERISATION OF THE CELLULAR AND MOLECULAR CHANGES IN THE HUMAN BRAIN AFTER RADIOTHERAPY
(Oxford University Press (OUP), 2023-09-08) -
Paediatrics: messages from Munich.
(2015-05)The aim of this article is to describe paediatric highlights from the 2014 European Respiratory Society (ERS) International Congress in Munich, Germany. Abstracts from the seven groups of the ERS Paediatric Assembly ... -
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
(Nature Research, 2020-07-10)A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an ...